Form Type: 4

SEC EDGAR Link
Accession Number:0000874015-14-000073
Date:2014-08-01
Issuer: ISIS PHARMACEUTICALS INC (ISIS)
Original Submission Date:

Reporting Person:

CROOKE STANLEY T
C/O ISIS PHARMACEUTICALS, INC.
2855 GAZELLE COURT CARLSBAD, CA 92010

Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
Title of SecurityTransaction Date2a. Deemed Execution Date Transaction CodeSharesAcquired or DisposedPrice per share 5. Amount of Securities Beneficially Owned Following Reported Transaction 6. Ownership Form Direct or IndirectNature of Indirect Ownership
COMMON STOCK 2014-08-01 M 15,000 a $14.47 21,941 direct
COMMON STOCK 2014-08-01 S 15,000 d $30.53 6,941 direct
COMMON STOCK 2014-08-01 M 1,000 a $11.27 1,627 indirect
COMMON STOCK 2014-08-01 S 1,000 d $30.53 627 indirect
COMMON STOCK 2014-08-01 0 $0.00 725,391 indirect
Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, convertible securities
Title of Derivative Security Conversion or Exercise Price of Derivative Security Transaction Date Deemed Execution Date Transaction Code Number of Derivative Securities Acquired (A) or Disposed of (D) Date ExercisableExpiration Date Title and Amount of Securities Underlying Derivative Security Price of Derivative Security Number of derivative Securities Beneficially Owned Following Reported Transaction(s) Ownership Form: Direct (D) or Indirect (I) Nature of Indirect Beneficial Ownership
EMPLOYEE STOCK OPTION (RIGHT TO BUY) 14.47 2014-08-01 deemed execution date M 15,000 (d) 2013-01-02 2016-01-01 common stock 15,000 $14.47 51,500 direct
EMPLOYEE STOCK OPTION (RIGHT TO BUY) 11.27 2014-08-01 deemed execution date M 1,000 (d) 2014-01-04 2017-01-03 common stock 1,000 $11.27 3,800 indirect by wife
Footnotes
IDfootnote
f1 acquired as a result of exercising a stock option pursuant to a rule 10b5-1 trading plan. the purchase and sale reported on this form 4 was effective pursuant to a rule 10b5-1 trading plan adopted by the reporting person on 8/6/13.
f2 acquired as a result of exercising a stock option pursuant to a rule 10b5-1 trading plan. the purchase and sale reported on this form 4 was effective pursuant to a rule 10b5-1 trading plan adopted by the reporting person's wife on 8/6/13.
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