Item 4 is hereby amended by adding the following paragraph as the third paragraph of such Item:
On April 23, 2014, the Issuer notified Dr. Rachesky that it has appointed Dr. Rachesky to serve as a Class I director on the Issuer’s
board of directors, effective as of June 1, 2014. On that same day, Dr. Rachesky notified the Issuer that he has accepted such appointment and has agreed to serve on the Issuer’s board of directors.
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