BAKER BROS. ADVISORS LP

• NEW YORK, NY • Investment Advisor • Hedge Fund • Activist Investor How do I update this listing?

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Baker Bros. Advisors is based out of New York. Baker Bros. Advisors is a hedge fund with 2 clients and discretionary assets under management (AUM) of $25,706,057,815 (Form ADV from 2022-03-28). Their last reported 13F filing for Q4 2022 included $16,651,382,602 in managed 13F securities and a top 10 holdings concentration of 86.98%. Baker Bros. Advisors's largest holding is Seagen Inc with shares held of 46,912,266. Baker Bros. Advisors has met the qualifications for inclusion in our WhaleScore system. Whalewisdom has at least 85 13F filings, 165 13D filings, 241 13G filings, and 140 Form 4 filings

12/31/2022

13F Activity

  • Market Value $16.651 Billion
  • Prior Market Value $15.269 Billion
  • New Purchases13 stocks
  • Additional Purchases17 stocks
  • Sold out of15 stocks
  • Reduced holdings in9 stocks
  • Top 10 Holdings % 86.98 %
  • Turnover % [1]:24.78%
  • Turnover Alt % [2]: 1.55 %
  • Time Held Top20:18.35 quarters
  • Time Held Top10:24.00 quarters
  • Time Held All:12.35 quarters

[1]: Turnover is calculated by taking the # of new holdings (initial purchases) + the # of positions sold out of (not just reduced) divided by the total # of holdings for the quarter.

[2]: Alt Turnover is calculated by taking either the total MV of new purchases or the MV of securities sold, whichever is less, divided by the total MV of the fund.

12/31/2022

13F Sector Allocation Over Time

Portfolio Performance

Top 20 equal-weighted holdings. Performance numbers calculated through 2023-02-14

Performance for Q4 2022: 12.04%
Performance Last 4 Quarters: 17.39%
Performance Metrics
Stdev (5-yrs): Subscription required BETA (5-yrs): Subscription required ALPHA (3-yrs): Subscription required
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Sterling (3-yrs): Subscription required Calmar (3-yrs): Subscription required Information Ratio (3-yrs): Subscription required
Tracking Error (3 yrs): Subscription required Stdev Down (3-yrs): Subscription required Winning Months %: Subscription required
Losing Months %: Subscription required Best 12 Months: Subscription required Worst 12 Months: Subscription required
Efficiency Ratio (3-yrs): Subscription required Sharpe: Subscription required Stdev Sectors: Subscription required
Skewness (3-yrs): Subscription required Kurtosis (3-yrs): Subscription required Upside Potential (3-yrs): Subscription required
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*Shares are split adjusted

Global (ex. US) Holdings

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Stale Holdings (no activity in past 21-months or sold out)

Source: Refinitiv. Stale holdings data removed after 21-months of inactivity.

View Last Form Adv Compilation Report on Record

BAKER BROTHERS INVESTMENTS
Classified as Hedge Fund
860 WASHINGTON STREET, 3RD FLOOR
NEW YORK NY    10014
Country: United States
Business Phone: 212-339-5600
Fax: 212-339-5688
Professional Investment Advisor Data
SEC Registration as : Large Advisory Firm
Form of Organization: Limited Partnership
Organized in: DE
Number of employees: 50
Other Business Activities:
Advisor Fees/Compensation: Percentage of assets under management,Performance-based fees
Amount of client funds and securities: 0
Total Number of Clients: 2
Amount of client funds and securities by related persons: 25,689,500,000
Total Number of clients from related persons: 2
Disclosures:
Data above was derived from SEC filings.

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Insider Transactions in the past year

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BAKER BROS. ADVISORS LP

ownership team - last updated 2022-03-28
Name Title Start Date Direct/Indirect % Ownership
BAKER, JULIAN, CHARLES LIMITED PARTNER 01/01/2000 Direct 25 - 50%
Fund Name Position direct/indirect start date end date
BAKER BROS. ADVISORS, LLC CO-MANAGING MEMBER direct 2000-01-01
BAKER BROS. ADVISORS LP MEMBER indirect 2000-01-01
BAKER BROS. ADVISORS (GP), LLC GENERAL PARTNER 01/01/2000 Direct less than 5%
Fund Name Position direct/indirect start date end date
BAKER BROS. ADVISORS LP GENERAL PARTNER direct 2000-01-01
LESSING, SCOTT, LAWRENCE PRESIDENT, CHIEF COMPLIANCE OFFICER 02/01/2011 Direct less than 5%
Fund Name Position direct/indirect start date end date
BAKER BROS. ADVISORS, LLC PRESIDENT, CHIEF COMPLIANCE OFFICER direct 2011-02-01
TOOHEY, ALEXANDRA, ANN CHIEF FINANCIAL OFFICER 01/01/2014 Direct less than 5%
Fund Name Position direct/indirect start date end date
ATTARA CAPITAL LP CHIEF EXECUTIVE OFFICER direct 2009-12-01
BAKER BROS. ADVISORS LP CHIEF FINANCIAL OFFICER direct 2014-01-01
BAKER, FELIX, JAMES LIMITED PARTNER 01/01/2000 Direct 25 - 50%
Fund Name Position direct/indirect start date end date
BAKER BROS. ADVISORS, LLC CO-MANAGING MEMBER direct 2000-01-01
BAKER BROS. ADVISORS LP MEMBER indirect 2000-01-01
BAKER, JULIAN, CHARLES MANAGING MEMBER BAKER BROS. ADVISORS (GP), LLC 01/01/2000 Indirect 50 - 75%
Fund Name Position direct/indirect start date end date
BAKER BROS. ADVISORS, LLC CO-MANAGING MEMBER direct 2000-01-01
BAKER BROS. ADVISORS LP MEMBER indirect 2000-01-01
BAKER, FELIX, JAMES MANAGING MEMBER BAKER BROS. ADVISORS (GP), LLC 01/01/2000 Indirect 50 - 75%
Fund Name Position direct/indirect start date end date
BAKER BROS. ADVISORS, LLC CO-MANAGING MEMBER direct 2000-01-01
BAKER BROS. ADVISORS LP MEMBER indirect 2000-01-01

Private Funds

Name Country Fund Identification Number Fund Type Gross Asset Value Minimum Investment Other
BAKER BROTHERS LIFE SCIENCES, L.P. United States 805-9378432489 Hedge Fund 23,423,422,192 40,000,000 Master Fund
667, L.P. United States 805-7902319250 Hedge Fund 2,266,121,438 40,000,000

BAKER BROS. ADVISORS LP

ownership team - last updated 2021-03-30
Name Title Start Date Direct/Indirect % Ownership
BAKER, JULIAN, CHARLES LIMITED PARTNER 01/01/2000 Direct 25 - 50%
Fund Name Position direct/indirect start date end date
BAKER BROS. ADVISORS, LLC CO-MANAGING MEMBER direct 2000-01-01
BAKER BROS. ADVISORS LP MEMBER indirect 2000-01-01
BAKER BROS. ADVISORS (GP), LLC GENERAL PARTNER 01/01/2000 Direct less than 5%
Fund Name Position direct/indirect start date end date
BAKER BROS. ADVISORS LP GENERAL PARTNER direct 2000-01-01
LESSING, SCOTT, LAWRENCE PRESIDENT, CHIEF COMPLIANCE OFFICER 02/01/2011 Direct less than 5%
Fund Name Position direct/indirect start date end date
BAKER BROS. ADVISORS, LLC PRESIDENT, CHIEF COMPLIANCE OFFICER direct 2011-02-01
TOOHEY, ALEXANDRA, ANN CHIEF FINANCIAL OFFICER 01/01/2014 Direct less than 5%
Fund Name Position direct/indirect start date end date
ATTARA CAPITAL LP CHIEF EXECUTIVE OFFICER direct 2009-12-01
BAKER BROS. ADVISORS LP CHIEF FINANCIAL OFFICER direct 2014-01-01
BAKER, FELIX, JAMES LIMITED PARTNER 01/01/2000 Direct 25 - 50%
Fund Name Position direct/indirect start date end date
BAKER BROS. ADVISORS, LLC CO-MANAGING MEMBER direct 2000-01-01
BAKER BROS. ADVISORS LP MEMBER indirect 2000-01-01
BAKER, JULIAN, CHARLES MANAGING MEMBER BAKER BROS. ADVISORS (GP), LLC 01/01/2000 Indirect 50 - 75%
Fund Name Position direct/indirect start date end date
BAKER BROS. ADVISORS, LLC CO-MANAGING MEMBER direct 2000-01-01
BAKER BROS. ADVISORS LP MEMBER indirect 2000-01-01
BAKER, FELIX, JAMES MANAGING MEMBER BAKER BROS. ADVISORS (GP), LLC 01/01/2000 Indirect 50 - 75%
Fund Name Position direct/indirect start date end date
BAKER BROS. ADVISORS, LLC CO-MANAGING MEMBER direct 2000-01-01
BAKER BROS. ADVISORS LP MEMBER indirect 2000-01-01

Private Funds

Name Country Fund Identification Number Fund Type Gross Asset Value Minimum Investment Other
BAKER BROTHERS LIFE SCIENCES, L.P. United States 805-9378432489 Hedge Fund 32,797,596,057 40,000,000 Master Fund
667, L.P. United States 805-7902319250 Hedge Fund 2,974,776,160 40,000,000

BAKER BROS. ADVISORS LP

ownership team - last updated 2020-03-25
Name Title Start Date Direct/Indirect % Ownership

Private Funds

Name Country Fund Identification Number Fund Type Gross Asset Value Minimum Investment Other
BAKER BROTHERS LIFE SCIENCES, L.P. United States 805-9378432489 Hedge Fund 21,642,241,082 40,000,000 Master Fund
14159, L.P. United States 805-9816274483 Hedge Fund 16,954,418 40,000,000
667, L.P. United States 805-7902319250 Hedge Fund 1,898,783,573 40,000,000

BAKER BROS. ADVISORS LP

ownership team - last updated 2019-03-18
Name Title Start Date Direct/Indirect % Ownership
BAKER, JULIAN, CHARLES LIMITED PARTNER 01/01/2000 Direct 25 - 50%
Fund Name Position direct/indirect start date end date
BAKER BROS. ADVISORS, LLC CO-MANAGING MEMBER direct 2000-01-01
BAKER BROS. ADVISORS LP MEMBER indirect 2000-01-01
BAKER BROS. ADVISORS (GP), LLC GENERAL PARTNER 01/01/2000 Direct less than 5%
Fund Name Position direct/indirect start date end date
BAKER BROS. ADVISORS LP GENERAL PARTNER direct 2000-01-01
LESSING, SCOTT, LAWRENCE PRESIDENT, CHIEF COMPLIANCE OFFICER 02/01/2011 Direct less than 5%
Fund Name Position direct/indirect start date end date
BAKER BROS. ADVISORS, LLC PRESIDENT, CHIEF COMPLIANCE OFFICER direct 2011-02-01
TOOHEY, ALEXANDRA, ANN CHIEF FINANCIAL OFFICER 01/01/2014 Direct less than 5%
Fund Name Position direct/indirect start date end date
ATTARA CAPITAL LP CHIEF EXECUTIVE OFFICER direct 2009-12-01
BAKER BROS. ADVISORS LP CHIEF FINANCIAL OFFICER direct 2014-01-01
BAKER, FELIX, JAMES LIMITED PARTNER 01/01/2000 Direct 25 - 50%
Fund Name Position direct/indirect start date end date
BAKER BROS. ADVISORS, LLC CO-MANAGING MEMBER direct 2000-01-01
BAKER BROS. ADVISORS LP MEMBER indirect 2000-01-01
BAKER, JULIAN, CHARLES MANAGING MEMBER BAKER BROS. ADVISORS (GP), LLC 01/01/2000 Indirect 50 - 75%
Fund Name Position direct/indirect start date end date
BAKER BROS. ADVISORS, LLC CO-MANAGING MEMBER direct 2000-01-01
BAKER BROS. ADVISORS LP MEMBER indirect 2000-01-01
BAKER, FELIX, JAMES MANAGING MEMBER BAKER BROS. ADVISORS (GP), LLC 01/01/2000 Indirect 50 - 75%
Fund Name Position direct/indirect start date end date
BAKER BROS. ADVISORS, LLC CO-MANAGING MEMBER direct 2000-01-01
BAKER BROS. ADVISORS LP MEMBER indirect 2000-01-01

Private Funds

Name Country Fund Identification Number Fund Type Gross Asset Value Minimum Investment Other
BAKER BROS. INVESTMENTS II, L.P. United States 805-8976652096 Hedge Fund 1,217,800 40,000,000
BAKER BROS. INVESTMENTS, L.P. United States 805-6854596471 Hedge Fund 9,815,602 40,000,000
BAKER BROTHERS LIFE SCIENCES, L.P. United States 805-9378432489 Hedge Fund 15,727,945,892 40,000,000 Master Fund
14159, L.P. United States 805-9816274483 Hedge Fund 64,063,878 40,000,000
BAKER/TISCH INVESTMENTS L.P. United States 805-3184499373 Hedge Fund 10,957,210 40,000,000
667, L.P. United States 805-7902319250 Hedge Fund 1,504,095,439 40,000,000

BAKER BROS. ADVISORS LP

ownership team - last updated 2017-09-28
Name Title Start Date Direct/Indirect % Ownership
BAKER, JULIAN, CHARLES CO-MANAGING MEMBER 01/01/2000 Direct 25 - 50%
Fund Name Position direct/indirect start date end date
BAKER BROS. ADVISORS, LLC CO-MANAGING MEMBER direct 2000-01-01
BAKER BROS. ADVISORS LP MEMBER indirect 2000-01-01
BAKER BROS. ADVISORS (GP), LLC GENERAL PARTNER 01/01/2000 Direct less than 5%
Fund Name Position direct/indirect start date end date
BAKER BROS. ADVISORS LP GENERAL PARTNER direct 2000-01-01
LESSING, SCOTT, LAWRENCE PRESIDENT, CHIEF COMPLIANCE OFFICER 02/01/2011 Direct less than 5%
Fund Name Position direct/indirect start date end date
BAKER BROS. ADVISORS, LLC PRESIDENT, CHIEF COMPLIANCE OFFICER direct 2011-02-01
TOOHEY, ALEXANDRA, ANN CHIEF FINANCIAL OFFICER 01/01/2014 Direct less than 5%
Fund Name Position direct/indirect start date end date
ATTARA CAPITAL LP CHIEF EXECUTIVE OFFICER direct 2009-12-01
BAKER BROS. ADVISORS LP CHIEF FINANCIAL OFFICER direct 2014-01-01
BAKER, FELIX, JAMES CO-MANAGING MEMBER 01/01/2000 Direct 25 - 50%
Fund Name Position direct/indirect start date end date
BAKER BROS. ADVISORS, LLC CO-MANAGING MEMBER direct 2000-01-01
BAKER BROS. ADVISORS LP MEMBER indirect 2000-01-01
BAKER, JULIAN, CHARLES MEMBER BAKER BROS. ADVISORS (GP), LLC 01/01/2000 Indirect 50 - 75%
Fund Name Position direct/indirect start date end date
BAKER BROS. ADVISORS, LLC CO-MANAGING MEMBER direct 2000-01-01
BAKER BROS. ADVISORS LP MEMBER indirect 2000-01-01
BAKER, FELIX, JAMES MEMBER BAKER BROS. ADVISORS (GP), LLC 01/01/2000 Indirect 50 - 75%
Fund Name Position direct/indirect start date end date
BAKER BROS. ADVISORS, LLC CO-MANAGING MEMBER direct 2000-01-01
BAKER BROS. ADVISORS LP MEMBER indirect 2000-01-01

Private Funds

Name Country Fund Identification Number Fund Type Gross Asset Value Minimum Investment Other
BAKER BROS. INVESTMENTS II, L.P. United States 805-8976652096 Hedge Fund 729,151 40,000,000
BAKER BROS. INVESTMENTS, L.P. United States 805-6854596471 Hedge Fund 5,667,849 40,000,000
BAKER BROTHERS LIFE SCIENCES, L.P. United States 805-9378432489 Hedge Fund 13,929,157,100 40,000,000 Master Fund
14159, L.P. United States 805-9816274483 Hedge Fund 131,197,451 40,000,000
BAKER/TISCH INVESTMENTS L.P. United States 805-3184499373 Hedge Fund 6,485,602 40,000,000
667, L.P. United States 805-7902319250 Hedge Fund 1,494,851,310 40,000,000

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