Form Type: 4

OMEGA FUND V, L.P.
888 BOYLSTON STREET, SUITE 1111
BOSTON, MA 02199

OMEGA FUND V GP, L.P.
888 BOYLSTON STREET, SUITE 1111
BOSTON, MA 02199

OMEGA FUND V GP MANAGER, LTD.
888 BOYLSTON STREET, SUITE 1111
BOSTON, MA 02199

STAMPACCHIA OTELLO
888 BOYLSTON STREET, SUITE 1111
BOSTON, MA 02199

Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
Title of Security	Transaction Date	Transaction Code	Shares	Acquired or Disposed	Price per share	5. Amount of Securities Beneficially Owned Following Reported Transaction	6. Ownership Form Direct or Indirect
COMMON STOCK	2019-09-16	S	13,213	d	$21.52	6,806,023 f4	direct
COMMON STOCK	2019-09-17	S	23,400	d	$21.62	6,782,623 f4	direct
COMMON STOCK	2019-09-18	S	45,600	d	$21.88	6,737,023 f4	direct

Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, convertible securities
Title of Derivative Security	Conversion or Exercise Price of Derivative Security	Transaction Date	Deemed Execution Date	Transaction Code	Number of Derivative Securities Acquired (A) or Disposed of (D)	Date Exercisable	Expiration Date	Title and Amount of Securities Underlying Derivative Security	Price of Derivative Security	Number of derivative Securities Beneficially Owned Following Reported Transaction(s)	Ownership Form: Direct (D) or Indirect (I)	Nature of Indirect Beneficial Ownership

Footnotes
ID	footnote
f1	the reported price in column 4 is a weighted average price. these shares were sold in multiple transactions at prices ranging from $21.50 to $21.56 per share, inclusive.
f2	the reported price in column 4 is a weighted average price. these shares were sold in multiple transactions at prices ranging from $21.50 to $22.24 per share, inclusive.
f3	the reported price in column 4 is a weighted average price. these shares were sold in multiple transactions at prices ranging from $21.50 to $22.35 per share, inclusive.
f4	the reported securities are held directly by omega fund v, l.p. ("omega v"). the reported securities may be deemed to be beneficially owned by each of omega fund v gp, l.p. ("omega v gp"), as the general partner of omega v, and omega fund v gp manager, ltd. ("omega v gp manager"), as the general partner of omega v gp. otello stampacchia, richard lim, anne-mari paster and claudio nessi (the "omega directors") are all the shareholders and directors of omega v gp manager and have shared voting and investment power over the shares held by omega v. each of omega v gp, omega fund v gp manager and the omega directors disclaims beneficial ownership of the securities reported herein, except to the extent of its or their pecuniary interest therein, if any. effective as of september 12, 2019, otello stampacchia is no longer a member of the issuer's board of directors.

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