|Issuer:||OPKO HEALTH, INC. (OPK)|
|Original Submission Date:|
FROST PHILLIP MD ET AL
OPKO HEALTH, INC.
4400 BISCAYNE BLVD. MIAMI, FL 33137
FROST GAMMA INVESTMENTS TRUST
4400 BISCAYNE BLVD.
MIAMI, FL 33137
|Title of Security||Transaction Date||2a. Deemed Execution Date||Transaction Code||Shares||Acquired or Disposed||Price per share||5. Amount of Securities Beneficially Owned Following Reported Transaction||6. Ownership Form Direct or Indirect||Nature of Indirect Ownership|
|Title of Derivative Security||Conversion or Exercise Price of Derivative Security||Transaction Date||Deemed Execution Date||Transaction Code||Number of Derivative Securities Acquired (A) or Disposed of (D)||Date Exercisable||Expiration Date||Title and Amount of Securities Underlying Derivative Security||Price of Derivative Security||Number of derivative Securities Beneficially Owned Following Reported Transaction(s)||Ownership Form: Direct (D) or Indirect (I)||Nature of Indirect Beneficial Ownership|
|f1||the securities are held by frost gamma investments trust, of which phillip frost m.d., is the trustee. frost gamma l.p. is the sole and exclusive beneficiary of frost gamma investments trust. dr. frost is one of two limited partners of frost gamma l.p. the general partner of frost gamma l.p. is frost gamma, inc., and the sole shareholder of frost gamma, inc. is frost-nevada corporation. dr. frost is also the sole shareholder of frost-nevada corporation. the reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of section 16 or for any other purpose.|
|f2||these securities are held by frost nevada investments trust, of which the reporting person is the trustee and frost-nevada, l.p. is the sole and exclusive beneficiary. the reporting person is one of seven limited partners of frost-nevada, l.p. and the sole shareholder of frost-nevada corporation, the sole general partner of frost-nevada, l.p. the reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of section 16 or for any other purpose.|