|Issuer:||SAGE THERAPEUTICS, INC. (SAGE)|
|Original Submission Date:|
GREENE BARRY E
C/O SAGE THERAPEUTICS, INC.
215 FIRST STREET CAMBRIDGE, MA 02142
|Title of Security||Transaction Date||2a. Deemed Execution Date||Transaction Code||Shares||Acquired or Disposed||Price per share||5. Amount of Securities Beneficially Owned Following Reported Transaction||6. Ownership Form Direct or Indirect||Nature of Indirect Ownership|
|Title of Derivative Security||Conversion or Exercise Price of Derivative Security||Transaction Date||Deemed Execution Date||Transaction Code||Number of Derivative Securities Acquired (A) or Disposed of (D)||Date Exercisable||Expiration Date||Title and Amount of Securities Underlying Derivative Security||Price of Derivative Security||Number of derivative Securities Beneficially Owned Following Reported Transaction(s)||Ownership Form: Direct (D) or Indirect (I)||Nature of Indirect Beneficial Ownership|
|f1||this transaction was executed in multiple trades at prices ranging from $56.12 usd to $56.41 usd. the price reported above reflects the weighted average purchase price. the issuer hereby undertakes to provide, upon request, to the sec staff or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.|