|Issuer:||ANNEXON, INC. (ANNX)|
|Original Submission Date:|
C/O ANNEXON, INC.
180 KIMBALL WAY, SUITE 200 SOUTH SAN FRANCISCO, CA 94080
|Title of Security||Transaction Date||2a. Deemed Execution Date||Transaction Code||Shares||Acquired or Disposed||Price per share||5. Amount of Securities Beneficially Owned Following Reported Transaction||6. Ownership Form Direct or Indirect||Nature of Indirect Ownership|
|Title of Derivative Security||Conversion or Exercise Price of Derivative Security||Transaction Date||Deemed Execution Date||Transaction Code||Number of Derivative Securities Acquired (A) or Disposed of (D)||Date Exercisable||Expiration Date||Title and Amount of Securities Underlying Derivative Security||Price of Derivative Security||Number of derivative Securities Beneficially Owned Following Reported Transaction(s)||Ownership Form: Direct (D) or Indirect (I)||Nature of Indirect Beneficial Ownership|
|STOCK OPTION (RIGHT TO BUY)||18.61||2021-09-30||deemed execution date||A||220,000 (a)||2031-09-30||common stock 220,000||$18.61||220,000||direct|
|f1||25% of the shares subject to the option vest on the first anniversary measured from september 30, 2021 (the "vesting commencement date"), and 1/48th of the total number of shares vest monthly thereafter, such that 100% of the shares subject to the option will be fully vested and exercisable on the fourth anniversary of the vesting commencement date.|