Form Type: 4

Accession Number:	0001209191-22-004346
Date:	2022-01-19
Issuer:	GRAPHITE BIO, INC. (GRPH)
Original Submission Date:

Reporting Person:

SAMSARA BIOCAPITAL, L.P.
628 MIDDLEFIELD ROAD
PALO ALTO, CA 94301

Reporting Person:

AKKARAJU SRINIVAS
628 MIDDLEFIELD ROAD
PALO ALTO, CA 94301

Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
Title of Security	Transaction Date	2a. Deemed Execution Date	Transaction Code	Shares	Acquired or Disposed	Price per share	5. Amount of Securities Beneficially Owned Following Reported Transaction	6. Ownership Form Direct or Indirect	Nature of Indirect Ownership
COMMON STOCK	2022-01-19		P	54,565	a	$9.24	7,868,745	indirect	f2
COMMON STOCK	2022-01-20		P	43,105	a	$8.92	7,911,850	indirect	f2
COMMON STOCK	2022-01-19			0		$0.00	37,753	indirect	f4

Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, convertible securities
Title of Derivative Security	Conversion or Exercise Price of Derivative Security	Transaction Date	Deemed Execution Date	Transaction Code	Number of Derivative Securities Acquired (A) or Disposed of (D)	Date Exercisable	Expiration Date	Title and Amount of Securities Underlying Derivative Security	Price of Derivative Security	Number of derivative Securities Beneficially Owned Following Reported Transaction(s)	Ownership Form: Direct (D) or Indirect (I)	Nature of Indirect Beneficial Ownership

Footnotes
ID	footnote
f1	the price reported in column 4 is a weighted average price. these shares were purchased in multiple transactions at prices ranging from $8.64 to $9.50 inclusive. the reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the securities and exchange commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote.
f2	shares are held by samsara biocapital, l.p. ("samsara lp"). samsara biocapital gp, llc ("samsara llc") is the general partner of samsara lp and may be deemed to beneficially own the shares held by samsara lp. dr. srinivas akkaraju, md, ph.d. has voting and investment power over the shares held by samsara lp and, accordingly, may be deemed to beneficially own the shares held by samsara lp. each of samsara llc and dr. akkaraju disclaims beneficial ownership in these shares except to the extent of his or its respective pecuniary interest therein.
f3	the price reported in column 4 is a weighted average price. these shares were purchased in multiple transactions at prices ranging from $8.83 to $8.95 inclusive. the reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the securities and exchange commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote.
f4	shares are held by 436, l.p. ("436 lp"). 436, llc ("436 llc") is the general partner of 436 lp and may be deemed to beneficially own the shares held by 436 lp. dr. srinivas akkaraju, md, ph.d. has voting and investment power over the shares held by 436 lp and, accordingly, may be deemed to beneficially own the shares held by 436 lp. dr. akkaraju disclaims beneficial ownership in these shares except to the extent of his pecuniary interest therein.

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