Form Type: 4

Accession Number:	0001209191-23-018561
Date:	2023-03-10
Issuer:	CRISPR THERAPEUTICS AG (CRSP)
Original Submission Date:

Reporting Person:

MORROW PHUONG KHANH
C/O CRISPR THERAPEUTICS, INC.
105 W FIRST STREET BOSTON, MA 02127

Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
Title of Security	Transaction Date	2a. Deemed Execution Date	Transaction Code	Shares	Acquired or Disposed	Price per share	5. Amount of Securities Beneficially Owned Following Reported Transaction	6. Ownership Form Direct or Indirect	Nature of Indirect Ownership

Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, convertible securities
Title of Derivative Security	Conversion or Exercise Price of Derivative Security	Transaction Date	Deemed Execution Date	Transaction Code	Number of Derivative Securities Acquired (A) or Disposed of (D)	Date Exercisable	Expiration Date	Title and Amount of Securities Underlying Derivative Security	Price of Derivative Security	Number of derivative Securities Beneficially Owned Following Reported Transaction(s)	Ownership Form: Direct (D) or Indirect (I)	Nature of Indirect Beneficial Ownership
STOCK OPTION (RIGHT TO BUY)	43.22	2023-03-10	deemed execution date	A	44,620 (a)		2033-03-10	common shares 44,620	$43.22	44,620	direct
RESTRICTED STOCK UNITS	0.0	2023-03-10	deemed execution date	A	22,000 (a)			common shares 22,000	$0.00	22,000	direct

Footnotes
ID	footnote
f1	this option was granted on march 10, 2023 with respect to 44,620 common shares. 100% of the shares will vest in 48 equal monthly installments, with the first vesting date of april 10, 2023.
f2	each restricted stock unit represents a contingent right to receive one share of crsp common shares.
f3	this restricted stock unit award was granted on march 10, 2023 with respect to 22,000 common shares, with (i) one quarter of the shares vesting on march 10, 2024, (ii) one quarter of the shares vesting on march 10, 2025, (iii) one quarter of the shares vesting on march 10, 2026, and (iv) one quarter of the shares vesting on march 10, 2027.

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