ADVM 13F Hedge Fund and Asset Management Owners

Data as of 2021-01-23
Market Cap	1.108 Billion	Shares Outstanding	97.478 Million	Avg 30-day Volume	1.141 Million
P/E Ratio	-10.5	Dividend Yield		EPS	-1.28
Price/Sales		Price cash flow ratio	242.9	Price free cash flow ratio	-19.4
Book Value	4.77	Price to Tangible Book	2.81	Alpha	0.02
Short Interest Ratio		% Short Interest to Float		R-squared	0.074537
BETA	1.71408	52-week High/Low	26.98 / 7.36	Stddev	0.276266

Q3 2020	All 13F Filers	Prior	Change	Hedge Funds ¹	Prior	Change
In top 10:	4	8	-50.0%	1 (0.07%)	4 (0.26%)	-75.0%
Funds Holding:	155	141	9.93%	51 (3.35%)	45 (2.92%)	13.33%
13F shares:	94.886 Million	80.872 Million	17.33%	48.535 Million	39.645 Million	22.42%
% Ownership	97.4871			49.8654	49.3736	1.0%
New Positions:	32	29	10.34%	15	11	36.36%
Increased Positions	65	59	10.17%	24	17	41.18%
Closed Positions	16	14	14.29%	9	9	0.0%
Reduced Positions	38	38	0.0%	10	15	-33.33%
Total Calls	659.965 Thousand	731.787 Thousand	-9.81%	467.7 Thousand	468.77 Thousand	-0.23%
Total Puts	414.556 Thousand	235.093 Thousand	76.34%	332.086 Thousand	156.8 Thousand	111.79%
PUT/CALL Ratio	0.63	0.32	96.88%	0.71	0.33	115.15%
¹ hedge funds and active managers as identified by whalewisdom.com through public filings.

Funds Holding ADVM (via 13F filings)

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Market Value:

Ranking:

% of portfolio

*Shares are split adjusted
*Please note that if a filer hasn't submitted a 13F filing for a quarter then the filer's shares will be listed as "Sold All"

Mutual Funds Holding ADVM BETA

Active Schedule 13D and 13G filings

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Open Market Buys/Sells Last 60 Days

Open Market Buys (P)

18.6 Thousand total shares from 2 transactions

Open Market Sells (S)

none

Exercise Derivative Conversion (M)

none

Current/Former Insiders

Insider Name	Type	Last Reported Shares Held	Last Reported Date	Filings in past year
MACHADO PATRICK	Director	78,182	2021-01-15	2
FISCHER LAURENT CEO AND DIRECTOR	Officer Director	16,292	2021-01-15	4
WOIWODE THOMAS	Director	18,822	2020-12-14	2
SVORONOS DAWN	Director	0	2020-12-09	2
SOPARKAR PETER CHIEF LEGAL OFFICER	Officer	10,692	2020-08-17	2
GASMI MEHDI	Director	274,442	2020-07-20	10
CARTER ERIC G	Director	0	2020-06-23	1
HEMRAJANI REKHA	Director	0	2020-06-23	1
SCOPA JAMES PAUL	Director	0	2020-06-23	3
LUPHER, JR. MARK L.	Director	0	2020-06-23	1
WHITCUP SCOTT M	Director	0	2020-06-23	3
PATTERSON LEONE D PRESIDENT	Officer	110,488	2020-06-16	7
THEDINGA ANGELA CHIEF TECHNOLOGY OFFICER	Officer	0	2020-02-21	2
OSBORNE AARON CHIEF MEDICAL OFFICER	Officer	0	2020-02-20	1
LEUNG THOMAS CHIEF FINANCIAL OFFICER	Officer	0	2020-02-20	1
FINER MITCHELL H.	Director	0	2019-07-31	0
SPIVEY RICHARD N.	Director	0	2019-07-31	0
CHENG JENNIFER C. GENERAL COUNSEL	Officer	0	2019-02-14	0
CLEVELAND PAUL B	Director	0	2018-05-31	0
SALZMAN AMBER PRESIDENT AND CEO	Officer Director	0	2018-02-15	0
COUNTOURIOTIS ATHENA SVP, CHIEF MEDICAL OFFICER	Officer	0	2018-02-15	0
SCHWARTZ STEVEN DANIEL	Director	398,991	2017-06-12	0
BARONE SAMUEL B. SVP, CLINICAL DEVELOPMENT	Officer	172,335	2017-02-09	0
RUSSO CARLO EVP AND CHIEF MEDICAL OFFICER	Officer	0	2016-05-11	0
VERSANT VENTURES IV, LLC VERSANT VENTURE CAPITAL IV, L.P. VERSANT IV LUXCO S.A R.L. VERSANT CAPITAL IV (SWITZERLAND) GMBH	10% Owner	7,003,892	2016-05-11	0
WACHTER PAUL	Director	69,112	2016-02-29	0
BLUMENKRANZ MARK S.	Director	562,915	2016-02-12	0
MCLAUGHLIN JOHN PETER	Director	36,893	2016-02-12	0
RUBIO ROMAN G. SVP, TRANSLATIONAL MEDICINE	Officer	165,650	2016-02-12	0
BRAUN SHIRLEY VP, HUMAN RESOURCES	Officer	161,140	2016-02-12	0
SWARTZBURG MICHAEL PRINCIPAL ACCOUNTING OFFICER	Officer	82,113	2016-02-12	0
BAIN LINDA CHIEF FINANCIAL OFFICER	Officer	41,930	2015-08-21	0
HULL HANS CHIEF EXECUTIVE OFFICER	Officer	137,210	2015-08-21	0
CHALBERG THOMAS W. CHIEF EXECUTIVE OFFICER	Officer Director	1,099,401	2015-06-10	0
GUERIN JOHN PATRICK ET AL	Director 10% Owner	200,000	2015-05-27	0
ZYGTECH, LLC	10% Owner	No longer subject to file	2015-04-13	0
REGENERON PHARMACEUTICALS INC	10% Owner	No longer subject to file	2014-08-05	0
FLYNN JAMES E DEERFIELD MGMT L.P. DEERFIELD SPECIAL SITUATIONS FUND, L.P. DEERFIELD SPECIAL SITUATIONS INTERNATIONAL MASTER FUND, L.P. DEERFIELD MGMT III, L.P. DEERFIELD MANAGEMENT CO DEERFIELD PRIVATE DESIGN FUND III, L.P. DEERFIELD PARTNERS, LP DEERFIELD INTERNATIONAL MASTER FUND, L.P.	10% Owner POSSIBLE MEMBERS OF 10% GROUPPOSSIBLE MEMBERS OF 10% GROUPPOSSIBLE MEMBERS OF 10% GROUPPOSSIBLE MEMBERS OF 10% GROUPPOSSIBLE MEMBERS OF 10% GROUPPOSSIBLE MEMBERS OF 10% GROUPPOSSIBLE MEMBERS OF 10% GROUPPOSSIBLE MEMBERS OF 10% GROUPPOSSIBLE MEMBERS OF 10% GROUP	No longer subject to file	2014-08-05	0
VENROCK ASSOCIATES VI, L.P. VENROCK PARTNERS VI, L.P. VENROCK MANAGEMENT VI, LLC VENROCK PARTNERS MANAGEMENT VI, LLC VENROCK HEALTHCARE CAPITAL PARTNERS LP VHCP CO-INVESTMENT HOLDINGS, LLC VHCP MANAGEMENT, LLC HOVE ANDERS D KOH BONG Y	10% Owner	2,365,471	2014-08-05	0
VENROCK HEALTHCARE CAPITAL PARTNERS II, L.P. VHCP CO-INVESTMENT HOLDINGS II, LLC VHCP MANAGEMENT II, LLC	10% Owner	2,365,471	2014-08-05	0
VENROCK ASSOCIATES VI, L.P. VENROCK PARTNERS VI, L.P. VENROCK MANAGEMENT VI, LLC VENROCK PARTNERS MANAGEMENT VI, LLC VENROCK HEALTHCARE CAPITAL PARTNERS LP VHCP CO-INVESTMENT HOLDINGS, LLC VHCP MANAGEMENT, LLC ROBERTS BRYAN E HOVE ANDERS D	10% Owner	0	2014-07-30	0
FLYNN JAMES E DEERFIELD MGMT L.P. DEERFIELD SPECIAL SITUATIONS INTERNATIONAL MASTER FUND, L.P. DEERFIELD SPECIAL SITUATIONS FUND, L.P. DEERFIELD MGMT III, L.P. DEERFIELD PRIVATE DESIGN FUND III, L.P.	10% Owner POSSIBLE MEMBER OF 10% GROUPPOSSIBLE MEMBER OF 10% GROUPPOSSIBLE MEMBER OF 10% GROUPPOSSIBLE MEMBER OF 10% GROUPPOSSIBLE MEMBER OF 10% GROUPPOSSIBLE MEMBER OF 10% GROUP	0	2014-07-30	0

Insider Transactions Last 60 Days

Reporting Owners	Filing Date	Trans Date	Trans Code	Shares	Share Price	Acquired Disposed	Shares Owned after	D/I	Perf 1d*	Perf 5d*	Max Gain	Max Gain Days	Max Loss	Max Loss Days
MACHADO PATRICK - Director	2021-01-19 20:33:27 -0500	2021-01-15	P	10,000	$11.52	a	78,182	direct	-3.592		0.0	1	-3.592	2
FISCHER LAURENT - Director - Officer CEO AND DIRECTOR	2021-01-19 20:32:40 -0500	2021-01-15	P	8,600	$11.53	a	16,292	direct	-3.592		0.0	1	-3.592	2
WOIWODE THOMAS - Director	2020-12-16 17:10:23 -0500	2020-12-14	J	12,783		a	18,822	direct	-2.9111	-3.3832	1.5736	4	-3.3832	6
SVORONOS DAWN - Director	2020-12-11 21:12:26 -0500	2020-12-09	A	45,000		a	45,000	direct

* -

Transaction Code Definitions
Code	Definition
A	Grant, award or other acquisition pursuant to Rule 16b-3(d)
C	Conversion of derivative security
D	Disposition to the issuer of issuer equity securities pursuant to Rule 16b-3(e)
E	Expiration of short derivative position
F	Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3
G	Bona fide gift
H	Expiration (or cancellation) of long derivative position with value received
I	Discretionary transaction in accordance with Rule 16b-3(f) resulting in acquisition or disposition of issuer securities
J	Other acquisition or disposition
L	Small acquisition under Rule 16a-6
M	Exercise or conversion of derivative security exempted pursuant to Rule 16b-3
O	Exercise of out-of-the-money derivative security
P	Open market or private purchase of non-derivative or derivative security
S	Open market or private sale of non-derivative or derivative security
U	Disposition pursuant to a tender of shares in a change of control transaction
W	Acquisition or disposition by will or the laws of descent and distribution
X	Exercise of in-the-money or at-the-money derivative security
Z	Deposit into or withdrawal from voting trust

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