Aeglea BioTherapeutics Inc (AGLE)

HEALTH CARE: PHARMACEUTICALS
SIC: PHARMACEUTICAL PREPARATIONS

805 LAS CIMAS PARKWAY AUSTIN, TX 78746

Aeglea BioTherapeutics is a clinical-stage biotechnology company redefining the potential of human enzyme therapeutics to benefit people with rare and devastating metabolic diseases with limited treatment options. Aeglea's lead product candidate, pegzilarginase, is in a pivotal Phase 3 trial for the treatment of Arginase 1 Deficiency and has received both Rare Pediatric Disease and Breakthrough Therapy Designation. In the second quarter of 2020, the Company initiated a Phase 1/2 clinical trial of AGLE-177 for the treatment of Homocystinuria. AGLE-177 has also been granted Rare Pediatric Disease Designation. Aeglea has an active discovery platform focused on engineering small changes in human enzymes to have a big impact on the lives of patients and their families.

Data as of 2021-07-19 09:34:05 -0400
Market Cap331.89 Million Shares Outstanding49.024 Million Avg 30-day Volume264.604 Thousand
P/E Ratio Dividend Yield EPS
Price/Sales Debt to Equity EBITDA
Price to Book Value0.0 Forward PE0.53 Enterprise Value
Total Cash Current Debt Gross Profit
BETA1.26476 52-week High/Low9.9 / 6.15 Next Earnings Date2021-08-10 Price to Cash FLow (P/CF) -18.3435
Data provided by IEX Cloud
View SEC Filings from AGLE instead.
Q1 2021 All 13F Filers Prior Change Hedge Funds 1 Prior Change
In top 10: 3 3 0.0% 1 (0.06%) 1 (0.06%) 0.0%
Funds Holding: 85 93 -8.6% 34 (2.0%) 36 (2.09%) -5.56%
13F shares: 41.471 Million 41.449 Million 0.05% 22.98 Million 23.831 Million -3.57%
% Ownership 86.3699 86.4661 -0.11% 47.8582 49.7134 -3.73%
New Positions: 3 10 -70.0% 3 4 -25.0%
Increased Positions 22 32 -31.25% 7 7 0.0%
Closed Positions 11 11 0.0% 5 7 -28.57%
Reduced Positions 33 29 13.79% 15 14 7.14%
Total Calls 42.604 Thousand 200 21202.0% 42.3 Thousand
Total Puts 15 Thousand 70 Thousand -78.57% 0 70 Thousand -100.0%
PUT/CALL Ratio 0.35 350.0 -99.9% 0.0 -100.0%
1 hedge funds and active managers as identified by whalewisdom.com through public filings.

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Funds Holding AGLE (via 13F filings)

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*Please note that if a filer hasn't submitted a 13F filing for a quarter then the filer's shares will be listed as "Sold All"

Mutual Funds Holding AGLE BETA

Active Schedule 13D and 13G filings

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Open Market Buys/Sells Last 60 Days

Open Market Buys (P)

none

Open Market Sells (S)

none

Exercise Derivative Conversion (M)

none

Current/Former Insiders

Insider Name Type Last Reported Shares Held Last Reported Date Filings in past year

ALSPAUGH JONATHAN CHIEF FINANCIAL OFFICER

  • Officer
0 2021-07-06 2

SOUZA MARCIO

  • Director
60,000 2021-06-18 2

SHANAFELT ARMEN

  • Director
40,000 2021-06-08 1

MAHATME SANDESH

  • Director
40,000 2021-06-08 1

COX RUSSELL J.

  • Director
40,000 2021-06-08 1

MAGOVCEVIC-LIEBISCH IVANA

  • Director
40,000 2021-06-08 1

LAWLIS V BRYAN

  • Director
40,000 2021-06-08 1

LAWTON ALISON FRANCES

  • Director
40,000 2021-06-08 3

BAKER BROS. ADVISORS LP

667, L.P.

BAKER BROS. ADVISORS (GP) LLC

BAKER BROTHERS LIFE SCIENCES LP

BAKER FELIX

BAKER JULIAN

  • Director
40,000 2021-06-08 3

BROWNSTEIN SARA

  • Director
0 2021-02-23 1

QUINN ANTHONY G. PRESIDENT & CEO

  • Officer
  • Director
0 2021-02-17 1

SLOAN LESLIE CHIEF OPERATING OFFICER

  • Officer
0 2021-02-17 1

HANLEY JR. MICHAEL CONICK CHIEF COMMERCIAL OFFICER

  • Officer
0 2021-02-17 1

WEBER STEVEN VP, CONTROLLER&PRINC ACCTG OFF

  • Officer
0 2021-02-17 2

BRUHN SUZANNE LOUISE

  • Director
0 2020-06-08 0

YORK CHARLES N II CHIEF FINANCIAL OFFICER AND VP

  • Officer
0 2020-02-14 0

RAO MADDURI RAVIN CHIEF MEDICAL OFFICER

  • Officer
0 2020-02-14 0

SCHUCHART AARON CHIEF BUSINESS OFFICER

  • Officer
0 2019-02-28 0

WOOLDRIDGE JAMES CHIEF MEDICAL OFFICER

  • Officer
0 2019-02-28 0

GEORGIOU GEORGE

  • Director
175,861 2018-08-13 0

NOVARTIS BIOVENTURES LTD

NOVARTIS AG

2,175,314 2018-05-11 0

TYLER JOSEPH E VP, MANUFACTURING

  • Officer
0 2017-08-22 0

ROWLINSON SCOTT W VP, RESEARCH

  • Officer
0 2017-08-22 0

LOWE DAVID GEORGE CEO AND PRESIDENT

  • Officer
  • Director
0 2017-03-20 0

HEBEL HENRY VP, PRODUCT DEVELOPMENT

  • Officer
0 2017-03-20 0

ORBIMED ADVISORS LLC

ORBIMED CAPITAL GP V LLC

ISALY SAMUEL D

  • 10% Owner
1,469,524 2017-02-16 0

ROJAS-CARO SANDRA CHIEF MEDICAL OFFICER

  • Officer
0 2016-05-17 0

LILLY ELI & CO

LILLY VENTURES FUND I LLC

SHANAFELT ARMEN

  • 10% Owner
2,068,543 2016-04-12 0

LILLY ELI & CO

  • 10% Owner
2,568,543 2016-04-12 0

LILLY VENTURES FUND I LLC

SHANAFELT ARMEN

TORRES S. EDWARD

  • Director
  • 10% Owner
57,619 2016-04-06 0

Insider Transactions Last 60 Days

Reporting Owners Filing Date Trans Date Trans Code Shares Share Price Acquired
Disposed
Shares Owned after D/I 10b5 Perf 1d* Perf 5d* Perf 1m* Max Gain Max Gain Days Max Loss Max Loss Days

ALSPAUGH JONATHAN - Officer CHIEF FINANCIAL OFFICER

2021-07-08 17:12:17 -0400 2021-07-06 A 160,000 a 160,000 direct

SOUZA MARCIO - Director

2021-06-22 16:07:02 -0400 2021-06-18 A 60,000 a 60,000 direct

MAHATME SANDESH - Director

2021-06-09 17:26:09 -0400 2021-06-08 A 40,000 a 40,000 direct

SHANAFELT ARMEN - Director

2021-06-09 17:27:11 -0400 2021-06-08 A 40,000 a 40,000 direct

LAWTON ALISON FRANCES - Director

2021-06-09 17:24:47 -0400 2021-06-08 A 40,000 a 40,000 direct

COX RUSSELL J. - Director

2021-06-09 17:23:00 -0400 2021-06-08 A 40,000 a 40,000 direct

MAGOVCEVIC-LIEBISCH IVANA - Director

2021-06-09 17:25:29 -0400 2021-06-08 A 40,000 a 40,000 direct

BAKER BROS. ADVISORS LP - Director see footnotes

667, L.P. - Director see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director see footnotes

BAKER FELIX - Director see footnotes

BAKER JULIAN - Director see footnotes

2021-06-10 16:31:24 -0400 2021-06-08 A 40,000 a 40,000 indirect

LAWLIS V BRYAN - Director

2021-06-09 17:23:50 -0400 2021-06-08 A 40,000 a 40,000 direct

* -

Transaction Code Definitions
Code Definition
A Grant, award or other acquisition pursuant to Rule 16b-3(d)
C Conversion of derivative security
D Disposition to the issuer of issuer equity securities pursuant to Rule 16b-3(e)
E Expiration of short derivative position
F Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3
G Bona fide gift
H Expiration (or cancellation) of long derivative position with value received
I Discretionary transaction in accordance with Rule 16b-3(f) resulting in acquisition or disposition of issuer securities
J Other acquisition or disposition
L Small acquisition under Rule 16a-6
M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3
O Exercise of out-of-the-money derivative security
P Open market or private purchase of non-derivative or derivative security
S Open market or private sale of non-derivative or derivative security
U Disposition pursuant to a tender of shares in a change of control transaction
W Acquisition or disposition by will or the laws of descent and distribution
X Exercise of in-the-money or at-the-money derivative security
Z Deposit into or withdrawal from voting trust

IBR Securities Loan Availability

Updated throughout the day, this shows the number of shares available to borrow. Data provided by Interactive Brokers

Security Date/Time Rebate Rate Fee Rate Shares Available
AEGLEA BIOTHERAPEUTICS INC AGLE 2021-07-26 22:15:03 UTC -0.4066 0.4866 500000
AEGLEA BIOTHERAPEUTICS INC AGLE 2021-07-26 21:45:04 UTC -0.4066 0.4866 500000
AEGLEA BIOTHERAPEUTICS INC AGLE 2021-07-26 21:15:03 UTC -0.4066 0.4866 500000
AEGLEA BIOTHERAPEUTICS INC AGLE 2021-07-26 20:45:03 UTC -0.4066 0.4866 500000
AEGLEA BIOTHERAPEUTICS INC AGLE 2021-07-26 20:15:04 UTC -0.4066 0.4866 500000
AEGLEA BIOTHERAPEUTICS INC AGLE 2021-07-26 19:45:02 UTC -0.4066 0.4866 500000
AEGLEA BIOTHERAPEUTICS INC AGLE 2021-07-26 19:15:03 UTC -0.4066 0.4866 500000
AEGLEA BIOTHERAPEUTICS INC AGLE 2021-07-26 18:45:03 UTC -0.4147 0.4947 500000
AEGLEA BIOTHERAPEUTICS INC AGLE 2021-07-26 18:15:03 UTC -0.4147 0.4947 500000
AEGLEA BIOTHERAPEUTICS INC AGLE 2021-07-26 17:45:02 UTC -0.4147 0.4947 500000
AEGLEA BIOTHERAPEUTICS INC AGLE 2021-07-26 17:15:03 UTC -0.4147 0.4947 500000
AEGLEA BIOTHERAPEUTICS INC AGLE 2021-07-26 16:45:03 UTC -0.4066 0.4866 500000
AEGLEA BIOTHERAPEUTICS INC AGLE 2021-07-26 16:15:03 UTC -0.4066 0.4866 500000
AEGLEA BIOTHERAPEUTICS INC AGLE 2021-07-26 15:45:03 UTC -0.4066 0.4866 500000
AEGLEA BIOTHERAPEUTICS INC AGLE 2021-07-26 15:15:03 UTC -0.4066 0.4866 500000
AEGLEA BIOTHERAPEUTICS INC AGLE 2021-07-26 14:45:03 UTC -0.4066 0.4866 500000
AEGLEA BIOTHERAPEUTICS INC AGLE 2021-07-26 14:15:03 UTC -0.4066 0.4866 500000
AEGLEA BIOTHERAPEUTICS INC AGLE 2021-07-26 13:45:03 UTC -0.4066 0.4866 500000
AEGLEA BIOTHERAPEUTICS INC AGLE 2021-07-26 13:15:02 UTC -0.4066 0.4866 500000
AEGLEA BIOTHERAPEUTICS INC AGLE 2021-07-26 12:45:03 UTC -0.4066 0.4866 500000

Current Active Short Positions

Holder Issuer Net Short Position Position Date Origin

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