Alpine Immune Sciences Inc (ALPN)

Sector:
HEALTH CARE
Industry:
BIOTECHNOLOGY & LIFE SCIENCES
SIC:
PHARMACEUTICAL PREPARATIONS
CEO:
Mitchell H. Gold
Employees:
80
201 ELLIOTT AVE. WEST, SUITE 230, SEATTLE, WA 98119
206-788-4545

Alpine Immune Sciences, Inc. focuses on the discovery and development of protein-based immunotherapies for the treatment of cancer, autoimmune/inflammatory disorders, and other diseases. Its product pipeline includes ALPN-101, an inducible T cell costimulator (ICOS)/cluster of differentiation 28 (CD28) antagonist program for the. treatment of autoimmune and inflammatory diseases.

Data derived from most recent annual or quarterly report
Market Cap 828.554 Million Shares Outstanding49.202 Million Avg 30-day Volume 588.695 Thousand
P/E Ratio0.0 Dividend Yield0.0 EPS-0.42
Price to Revenue16.9609 Debt to Equity0.0 EBITDA-69.491 Million
Price to Book Value2.9161 Operating Margin-224.7296 Enterprise Value254.592 Million
Current Ratio3.882 EPS Growth0.255 Quick Ratio3.821
1 Yr BETA 1.4097 52-week High/Low 17.25 / 5.81 Profit Margin-201.0748
Operating Cash Flow Growth-1717.0742 Free Cash Flow to Firm (FCFF) TTM -71.499 Million Free Cash Flow to Equity (FCFE) TTM-40.532 Million
Altman Z-Score2.156
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Funds Holding ALPN (via 13F filings)

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Recent Filings

Financial Reporting

Ownership

  • 4: filed on 2023-11-14 by CUI XIANGMIN
  • 4: filed on 2023-10-04 by DUMMER WOLFGANG
  • 3: filed on 2023-10-04 by DUMMER WOLFGANG
  • 3: filed on 2023-04-27 by DURAND REMY
  • 4: filed on 2023-01-05 by SANDLER ANDREW SETH
  • 4: filed on 2023-01-05 by THOMPSON PETER A.
  • 4: filed on 2023-01-05 by GOLD MITCHELL
  • 4: filed on 2023-01-05 by RICKEY JAMES PAUL
  • 4: filed on 2023-01-05 by PENG STANFORD L
  • 4: filed on 2023-01-05 by TOPPER JAMES N

    • Events (8k)

  • 8-K: filed on 2023-11-14:
    Item 2.02: Results of Operations and Financial Condition
    Item 7.01: Regulation FD Disclosure
    Item 9.01: Financial Statements and Exhibits
  • 8-K: filed on 2023-11-08:
    Item 1.01: Entry into a Material Definitive Agreement
    Item 8.01: Other Events
    Item 9.01: Financial Statements and Exhibits
  • 8-K: filed on 2023-11-06:
    Item 2.02: Results of Operations and Financial Condition
  • 8-K: filed on 2023-11-02:
    Item 8.01: Other Events
    Item 9.01: Financial Statements and Exhibits
  • 8-K: filed on 2023-08-14:
    Item 2.02: Results of Operations and Financial Condition
    Item 7.01: Regulation FD Disclosure
    Item 9.01: Financial Statements and Exhibits
  • 8-K: filed on 2023-06-14:
    Item 5.07: Submission of Matters to a Vote of Security Holders
    Item 9.01: Financial Statements and Exhibits
  • 8-K: filed on 2023-05-11:
    Item 2.02: Results of Operations and Financial Condition
    Item 7.01: Regulation FD Disclosure
    Item 9.01: Financial Statements and Exhibits
  • 8-K: filed on 2023-04-28:
    Item 1.01: Entry into a Material Definitive Agreement
    Item 9.01: Financial Statements and Exhibits
  • 8-K: filed on 2023-03-23:
    Item 2.02: Results of Operations and Financial Condition
    Item 7.01: Regulation FD Disclosure
    Item 9.01: Financial Statements and Exhibits
  • 8-K: filed on 2023-01-26:
    Item 5.03: Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year
    Item 9.01: Financial Statements and Exhibits

    • Proposed Sales (Form 144)

  • 144: filed on 2023-12-08:
  • 144: filed on 2023-11-06:

    • Proxy

    Prospectus

    All

    Open Market Buys/Sells Last 60 Days

    Open Market Buys (P)

    750 Thousand total shares from 2 transactions

    Open Market Sells (S)

    89.5 Thousand total shares from 5 transactions

    Exercise Derivative Conversion (M)

    82.5 Thousand total shares from 5 transactions

    Current/Former Insiders

    Insider Name Type Last Reported Shares Held Last Reported Date Filings in past year

    RICKEY JAMES PAUL SEE REMARKS

    • Officer
    		 0 2023-12-04 4

    CUI XIANGMIN

    • Director
    • 10% Owner
    		 7,083,288 2023-11-09 2

    DECHENG CAPITAL GLOBAL HEALTHCARE FUND (MASTER), LP

    DECHENG CAPITAL GLOBAL HEALTHCARE GP, LLC

    • 10% Owner
    		 1,735,544 2023-11-09 1

    DUMMER WOLFGANG CHIEF MEDICAL OFFICER

    • Officer
    		 0 2023-10-02 2

    DURAND REMY CHIEF BUSINESS OFFICER

    • Officer
    		 6,904 2023-04-21 1

    SANDLER ANDREW SETH CHIEF MEDICAL OFFICER

    • Officer
    		 50,000 2023-01-05 1

    GOLD MITCHELL EXECUTIVE CHAIRMAN AND CEO

    • Officer
    • Director
    		 350,000 2023-01-04 1

    PENG STANFORD L SEE REMARKS

    • Officer
    		 150,000 2023-01-04 1

    CONWAY ROBERT E

    • Director
    		 10,000 2023-01-03 1

    TOPPER JAMES N

    • Director
    		 10,000 2023-01-03 1

    THOMPSON PETER A.

    • Director
    		 10,000 2023-01-03 1

    PEETZ CHRISTOPHER

    • Director
    		 10,000 2023-01-03 1

    HERNDAY NATASHA

    • Director
    		 10,000 2023-01-03 1

    DRAPPA JORN

    • Director
    		 10,000 2023-01-03 1

    DECHENG CAPITAL CHINA LIFE SCIENCES USD FUND III, L.P.

    DECHENG CAPITAL MANAGEMENT III (CAYMAN), LLC

    • 10% Owner
    		 6,708,288 2022-09-23 0

    VENKATESAN JAY

    • Director
    • 10% Owner
    		 2,876,372 2022-07-15 0

    FRAZIER LIFE SCIENCES VIII, L.P.

    FHM LIFE SCIENCES VIII, L.P.

    FHM LIFE SCIENCES VIII, L.L.C.

    HERON PATRICK J

    TOPPER JAMES N

    • Director
    • 10% Owner
    		 1,484,115 2022-02-11 1

    ORBIMED ADVISORS LLC

    ORBIMED CAPITAL GP VI LLC

    ORBIMED GENESIS GP LLC

    • Director
    • 10% Owner
    		 4,081,592 2021-09-17 0

    ALPINE IMMUNOSCIENCES, L.P.

    ALPINE BIOVENTURES, GP, LLC

    • 10% Owner
    		 2,600,980 2021-09-17 0

    GOLDBERG ZELANNA CHIEF MEDICAL OFFICER

    • Officer
    		 0 2021-06-01 0

    ORBIMED ADVISORS LLC

    ORBIMED CAPITAL GP VI LLC

    • Director
    • 10% Owner
    		 3,070,955 2020-12-28 0

    SEKHRI PAUL J

    • Director
    		 0 2020-01-02 0

    TIGER MANAGEMENT L.L.C.

    • 10% Owner
    		 No longer subject to file 2019-02-08 0

    LITTON MARK JAMES SEE REMARKS

    • Officer
    		 0 2019-02-06 0

    FRAZIER LIFE SCIENCES VIII, L.P.

    FHM LIFE SCIENCES VIII, L.P.

    FHM LIFE SCIENCES VIII, L.L.C.

    HERON PATRICK J

    • 10% Owner
    		 2,716,701 2019-01-18 0

    ORBIMED ADVISORS LLC

    ORBIMED CAPITAL GP VI LLC

    ISALY SAMUEL D

    • Director
    		 0 2017-07-24 0

    BVF PARTNERS L P/IL

    BIOTECHNOLOGY VALUE FUND L P

    BIOTECHNOLOGY VALUE FUND II LP

    BIOTECHNOLOGY VALUE TRADING FUND OS LP

    BVF PARTNERS OS LTD.

    BVF INC/IL

    LAMPERT MARK N

    • 10% Owner
    • SEE EXPLANATION OF RESPONSESSEE EXPLANATION OF RESPONSESSEE EXPLANATION OF RESPONSESSEE EXPLANATION OF RESPONSES
    		2,028,158 2017-06-20 0

    TROHA JANICE EXEC VICE PRESIDENT / COO

    • Officer
    		 10,000 2017-05-05 0

    CARRUTHERS R MICHAEL INTERIM PRESIDENT / CFO

    • Officer
    		 0 2017-01-12 0

    RODMAN DAVID MALCOM EXEC VICE PRESIDENT AND CMO

    • Officer
    		 11,368 2017-01-03 0

    SMITH CYNTHIA

    • Director
    		 0 2016-11-01 0

    FLYNN JAMES E

    DEERFIELD MANAGEMENT CO

    • Director
    • 10% Owner
    		 0 2016-09-12 0

    MOORE JOHN R

    • Director
    		 0 2016-09-12 0

    FURST HOWARD P.

    • Director
    		 0 2016-09-12 0

    LOH EVAN

    • Director
    		 0 2016-09-12 0

    CONGLETON JON PRESIDENT AND CEO

    • Officer
    • Director
    		 0 2016-09-12 0

    LEFF JONATHAN S

    • Director
    		 0 2015-09-11 0

    SHOEMAKER STEVEN VP CLINICAL R&D

    • Officer
    		 0 2015-09-11 0

    GABRIEL SHERIF VICE PRESIDENT RESEARCH

    • Officer
    		 0 2015-09-11 0

    FLYNN JAMES E

    DEERFIELD MGMT L.P.

    DEERFIELD MANAGEMENT CO

    DEERFIELD SPECIAL SITUATIONS FUND, L.P.

    DEERFIELD PRIVATE DESIGN FUND L P

    DEERFIELD PRIVATE DESIGN FUND II, L.P.

    DEERFIELD PRIVATE DESIGN INTERNATIONAL, L.P.

    DEERFIELD PRIVATE DESIGN INTERNATIONAL II, L.P.

    • 10% Owner
    • POSSIBLE MEMBER OF 10% GROUPPOSSIBLE MEMBER OF 10% GROUPPOSSIBLE MEMBER OF 10% GROUPPOSSIBLE MEMBER OF 10% GROUPPOSSIBLE MEMBER OF 10% GROUPPOSSIBLE MEMBER OF 10% GROUPPOSSIBLE MEMBER OF 10% GROUPPOSSIBLE MEMBER OF 10% GROUP
    		 3,732,412 2015-06-23 0

    ROCK SPRINGS CAPITAL MANAGEMENT LP

    • 10% Owner
    		 No longer subject to file 2015-06-22 0

    HADLEY HARBOR MASTER INVESTORS (CAYMAN) L.P.

    • 10% Owner
    		 No longer subject to file 2015-06-22 0

    JENNISON GLOBAL HEALTHCARE MASTER FUND, LTD.

    • 10% Owner
    		 No longer subject to file 2015-06-22 0

    ESTATE OF ARNOLD H. SNIDER, III

    • 10% Owner
    		 1,557,228 2015-06-22 0

    HAWKES BAY MASTER INVESTORS (CAYMAN) L.P.

    • 10% Owner
    		 No longer subject to file 2015-06-19 0

    FLYNN JAMES E

    DEERFIELD MGMT L.P.

    DEERFIELD MANAGEMENT CO

    DEERFIELD PRIVATE DESIGN FUND L P

    DEERFIELD PRIVATE DESIGN INTERNATIONAL, L.P.

    DEERFIELD PRIVATE DESIGN FUND II, L.P.

    DEERFIELD PRIVATE DESIGN INTERNATIONAL II, LTD.

    DEERFIELD SPECIAL SITUATIONS FUND, L.P.

    • 10% Owner
    • POSSIBLE MEMBER OF 10% GROUPPOSSIBLE MEMBER OF 10% GROUPPOSSIBLE MEMBER OF 10% GROUPPOSSIBLE MEMBER OF 10% GROUPPOSSIBLE MEMBER OF 10% GROUPPOSSIBLE MEMBER OF 10% GROUP
    		404,022 2015-06-16 0

    TIGER PARTNERS LP

    TIGER PARTNERS GP, LLC

    • 10% Owner
    		 650,915 2015-06-16 0

    PATTISON RONALD L.

    • Director
    		 501,828 2011-03-14 0

    Insider Transactions Last 60 Days

    Reporting Owners Filing Date Trans Date Trans Code Shares Share Price Acquired
    Disposed    		 Shares Owned after D/I 10b5 Perf 1d* Perf 5d* Perf 1m* Max Gain Max Gain Days Max Loss Max Loss Days

    RICKEY JAMES PAUL - Officer SEE REMARKS

    		2023-12-06 19:31:13 -0500 2023-12-06 M 6,446 d 19,500 direct yes

    RICKEY JAMES PAUL - Officer SEE REMARKS

    		2023-12-06 19:31:13 -0500 2023-12-06 S 6,446 $16.08 d 0 direct yes 1.937 1.937 2 0.0 1

    RICKEY JAMES PAUL - Officer SEE REMARKS

    		2023-12-06 19:31:13 -0500 2023-12-06 M 6,446 $3.23 a 6,446 direct yes 1.937 1.937 2 0.0 1

    RICKEY JAMES PAUL - Officer SEE REMARKS

    		2023-12-06 19:31:13 -0500 2023-12-05 M 418 d 25,946 direct yes

    RICKEY JAMES PAUL - Officer SEE REMARKS

    		2023-12-06 19:31:13 -0500 2023-12-05 S 418 $16.01 d 0 direct yes 1.937 1.937 2 0.0 1

    RICKEY JAMES PAUL - Officer SEE REMARKS

    		2023-12-06 19:31:13 -0500 2023-12-05 M 418 $3.23 a 418 direct yes 1.937 1.937 2 0.0 1

    RICKEY JAMES PAUL - Officer SEE REMARKS

    		2023-12-06 19:31:13 -0500 2023-12-04 M 63,947 d 26,364 direct yes

    RICKEY JAMES PAUL - Officer SEE REMARKS

    		2023-12-06 19:31:13 -0500 2023-12-04 S 63,947 $16.06 d 0 direct yes 1.937 1.937 2 0.0 1

    RICKEY JAMES PAUL - Officer SEE REMARKS

    		2023-12-06 19:31:13 -0500 2023-12-04 M 63,947 $3.23 a 63,947 direct yes 1.937 1.937 2 0.0 1

    RICKEY JAMES PAUL - Officer SEE REMARKS

    		2023-12-01 17:00:44 -0500 2023-11-30 M 700 d 90,311 direct yes

    RICKEY JAMES PAUL - Officer SEE REMARKS

    		2023-12-01 17:00:44 -0500 2023-11-30 S 700 $16.00 d 0 direct yes -4.1199 0.0 1 -4.1199 2

    RICKEY JAMES PAUL - Officer SEE REMARKS

    		2023-12-01 17:00:44 -0500 2023-11-30 M 700 $3.23 a 700 direct yes -4.1199 0.0 1 -4.1199 2

    CUI XIANGMIN - Director - > 10% Owner see footnote

    		2023-11-14 17:33:22 -0500 2023-11-09 P 375,000 $12.50 a 1,735,544 indirect 0.2375 9.0261 11.0847 4 0.0 1

    DECHENG CAPITAL GLOBAL HEALTHCARE FUND (MASTER), LP - > 10% Owner

    DECHENG CAPITAL GLOBAL HEALTHCARE GP, LLC - > 10% Owner

    		2023-11-14 17:36:42 -0500 2023-11-09 P 375,000 $12.50 a 1,735,544 direct 0.2375 9.0261 11.0847 4 0.0 1

    RICKEY JAMES PAUL - Officer SEE REMARKS

    		2023-11-08 17:20:54 -0500 2023-11-06 S 18,003 $16.03 d 0 direct yes 1.3267 4.9751 4.9751 6 -4.1459 3

    RICKEY JAMES PAUL - Officer SEE REMARKS

    		2023-11-08 17:20:54 -0500 2023-11-06 M 10,989 d 91,011 direct yes

    RICKEY JAMES PAUL - Officer SEE REMARKS

    		2023-11-08 17:20:54 -0500 2023-11-06 M 10,989 $3.23 a 18,003 direct yes 1.3267 4.9751 4.9751 6 -4.1459 3

    * -

    Transaction Code Definitions
    Code Definition
    A Grant, award or other acquisition pursuant to Rule 16b-3(d)
    C Conversion of derivative security
    D Disposition to the issuer of issuer equity securities pursuant to Rule 16b-3(e)
    E Expiration of short derivative position
    F Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3
    G Bona fide gift
    H Expiration (or cancellation) of long derivative position with value received
    I Discretionary transaction in accordance with Rule 16b-3(f) resulting in acquisition or disposition of issuer securities
    J Other acquisition or disposition
    L Small acquisition under Rule 16a-6
    M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3
    O Exercise of out-of-the-money derivative security
    P Open market or private purchase of non-derivative or derivative security
    S Open market or private sale of non-derivative or derivative security
    U Disposition pursuant to a tender of shares in a change of control transaction
    W Acquisition or disposition by will or the laws of descent and distribution
    X Exercise of in-the-money or at-the-money derivative security
    Z Deposit into or withdrawal from voting trust

    IBR Securities Loan Availability

    Updated throughout the day, this shows the number of shares available to borrow. Data provided by Interactive Brokers

    Security Date/Time Rebate Rate Fee Rate Shares Available
    ALPINE IMMUNE SCIENCES INC ALPN 2023-12-08 22:15:04 UTC 4.4973 0.8227 650000
    ALPINE IMMUNE SCIENCES INC ALPN 2023-12-08 21:45:04 UTC 4.4973 0.8227 650000
    ALPINE IMMUNE SCIENCES INC ALPN 2023-12-08 21:15:04 UTC 4.4973 0.8227 650000
    ALPINE IMMUNE SCIENCES INC ALPN 2023-12-08 20:45:04 UTC 4.4973 0.8227 650000
    ALPINE IMMUNE SCIENCES INC ALPN 2023-12-08 20:15:07 UTC 4.4973 0.8227 650000
    ALPINE IMMUNE SCIENCES INC ALPN 2023-12-08 19:45:04 UTC 4.4973 0.8227 650000
    ALPINE IMMUNE SCIENCES INC ALPN 2023-12-08 19:15:03 UTC 4.4973 0.8227 650000
    ALPINE IMMUNE SCIENCES INC ALPN 2023-12-08 18:45:03 UTC 4.4973 0.8227 650000
    ALPINE IMMUNE SCIENCES INC ALPN 2023-12-08 18:15:04 UTC 4.4973 0.8227 650000
    ALPINE IMMUNE SCIENCES INC ALPN 2023-12-08 17:45:03 UTC 4.4451 0.8749 650000
    ALPINE IMMUNE SCIENCES INC ALPN 2023-12-08 17:15:03 UTC 4.4451 0.8749 650000
    ALPINE IMMUNE SCIENCES INC ALPN 2023-12-08 16:45:05 UTC 4.4451 0.8749 650000
    ALPINE IMMUNE SCIENCES INC ALPN 2023-12-08 16:15:04 UTC 4.4451 0.8749 650000
    ALPINE IMMUNE SCIENCES INC ALPN 2023-12-08 15:45:04 UTC 4.4451 0.8749 650000
    ALPINE IMMUNE SCIENCES INC ALPN 2023-12-08 15:15:04 UTC 4.4451 0.8749 650000
    ALPINE IMMUNE SCIENCES INC ALPN 2023-12-08 14:45:04 UTC 4.4451 0.8749 650000
    ALPINE IMMUNE SCIENCES INC ALPN 2023-12-08 14:15:03 UTC 4.4451 0.8749 650000
    ALPINE IMMUNE SCIENCES INC ALPN 2023-12-08 13:45:03 UTC 4.558 0.762 650000
    ALPINE IMMUNE SCIENCES INC ALPN 2023-12-08 13:15:04 UTC 4.558 0.762 650000
    ALPINE IMMUNE SCIENCES INC ALPN 2023-12-08 12:45:05 UTC 4.558 0.762 650000

    Current Active Short Positions

    Holder Issuer Net Short Position Position Date Origin

    No recent transactions

    *** To see all congressional transactions (since 2022) for this stock, please use the congressional transaction search page***

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