Genomic Health Inc (GHDX)

HEALTH CARE: PHARMACEUTICALS
SIC: SERVICES-MEDICAL LABORATORIES

301 PENOBSCOT DRIVE REDWOOD CITY, CA 94063

Focuses on the development and commercialization of genomic-based clinical diagnostic tests for cancer. The company's principal product is the Oncotype DX genomic test. It also has a clinical development program including tests to predict responsiveness to specific chemotherapies.

Data based on most recent fiscal year report
Market Cap1.089 Billion Shares Outstanding34.79 Million Avg Volume222.098 Thousand
1-Yr BETA vs S&P TR1.615 Current Ratio4.41 Quick Ratio4.41
View SEC Filings from GHDX instead.
Q1 2019 All Institutions Hedge Funds 1
To trade GHDX now:
Filers who had this stock in their top 10: 1 1 (0.1%)
13F Filers holding this stock: 258 40 (4.08%)
Aggregate 13F shares on 03/31/2019: 35.327 Million 15.366 Million
Aggregate 13F shares on 12/31/2018: 33.394 Million 16.231 Million
Percent change: 5.79% -5.33%
Funds creating new positions: 59 8
Funds Adding to an existing position: 101 14
Funds closing out their position: 22 2
Funds reducing their position: 69 17
1 hedge funds as identified by whalewisdom.com through public filings.

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Funds Holding GHDX (via 13F filings)

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Open Market Buys/Sells Last 60 Days

Open Market Buys (P)

none

Open Market Sells (S)

1.1 Million total shares from 127 transactions

Exercise Derivative Conversion (M)

33.9 Thousand total shares from 7 transactions

Current/Former Insiders

Insider Name Type Last Reported Shares Held Last Reported Date Filings in past year

PARKER GEOFFREY M.

  • Director
 10,943 2019-05-15 1

COLE G BRADLEY CFO

  • Officer
 43,722 2019-05-14 12

SHAK STEVEN CHIEF SCIENTIFIC OFFICER

  • Officer
 233,479 2019-05-08 16

VAUGHN JAMES J CHIEF COMMERCIAL OFFICER

  • Officer
 20,420 2019-05-08 13

SCOTT RANDAL W EXECUTIVE CHAIRMAN

  • Officer
  • Director
 0 2019-05-02 0

FLANNELLY BARRY P

  • Director
 0 2019-04-16 2

HOOF TORSTEN CHIEF INT'L COMMERCIAL OFFICER

  • Officer
 14,867 2019-04-16 1

BAKER BROS. ADVISORS LP

BAKER BROS. INVESTMENTS, L.P.

BAKER/TISCH INVESTMENTS, LP

14159, L.P.

667, L.P.

BAKER BROS. ADVISORS (GP) LLC

BAKER BROTHERS LIFE SCIENCES LP

BAKER FELIX

BAKER JULIAN

BAKER BROS. INVESTMENTS II, L.P.

  • Director
  • 10% Owner
 9,648,204 2019-04-12 30

POPOVITS KIMBERLY J PRESIDENT AND CEO

  • Officer
  • Director
 157,418 2019-04-08 12

COHEN FRED E

  • Director
 73,836 2019-04-01 8

GRAHAM GINGER L

  • Director
 51,952 2019-04-01 8

FUCHS HENRY J

  • Director
 6,481 2019-04-01 5

SCHORNO DEAN L EVP &CHIEF FINANCIAL OFFICER

  • Officer
 0 2019-03-20 0

PLA FREDERIC COO

  • Officer
 31,575 2019-03-18 9

LEBER LAURA CHIEF COMMUNICATION OFFICER

  • Officer
 17,032 2019-02-20 4

RADFORD JASON W. CHIEF LEGAL OFFICER

  • Officer
 34,888 2019-02-19 5

MCEACHRON KIM CHIEF PEOPLE OFFICER

  • Officer
 36,077 2019-02-15 2

COLELLA SAMUEL D

  • Director
 158,053 2019-02-12 0

MYERS WOODROW A JR

  • Director
 0 2018-12-20 0

BAKER BROS. ADVISORS LP

BAKER BROTHERS LIFE SCIENCES LP

BAKER FELIX

BAKER JULIAN

BAKER BROS. ADVISORS LP

BAKER BROS. INVESTMENTS II, L.P.

BAKER BROTHERS LIFE SCIENCES LP

BAKER BROS. INVESTMENTS, L.P.

BAKER FELIX

BAKER JULIAN

BAKER/TISCH INVESTMENTS, LP

BAKER BROS. INVESTMENTS II, L.P.

14159, L.P.

BAKER BROS. INVESTMENTS, L.P.

667, L.P.

BAKER/TISCH INVESTMENTS, LP

BAKER BROS. ADVISORS (GP) LLC

14159, L.P.

667, L.P.

BAKER BROS. ADVISORS (GP) LLC

  • Director
  • 10% Owner
 52,893,409 2018-11-16 30

LIVINGSTON RANDALL S

  • Director
 64,704 2018-08-01 0

FEBBO PHILLIP G. CHIEF MEDICAL OFFICER

  • Officer
 21,387 2018-02-20 0

BYERS BROOK H

  • FORMER DIRECTOR
 No longer subject to file 2016-07-01 0

BAKER FELIX

  • Director
  • 10% Owner
 10,170,173 2015-06-22 0

HIBBS KATHY L SVP & GENERAL COUNSEL

  • Officer
 15,787 2014-02-15 0

BAKER BROS. ADVISORS (GP) LLC

  • Director
  • 10% Owner
 0 2013-07-01 0

14159, L.P.

  • Director
 370,839 2013-06-11 0

667, L.P.

  • Director
 2,038,937 2013-06-11 0

BAKER BROTHERS LIFE SCIENCES LP

  • Director
 12,445,783 2013-06-11 0

BAKER JULIAN

BAKER FELIX

BAKER BROS ADVISORS LLC

667, L.P.

BAKER BROTHERS LIFE SCIENCES LP

14159, L.P.

  • Director
  • 10% Owner
 15,023,952 2013-06-11 0

BAKER FELIX

BAKER BROS. INVESTMENTS, L.P.

BAKER BROS. INVESTMENTS II, L.P.

BAKER/TISCH INVESTMENTS, LP

667, L.P.

BAKER BROTHERS LIFE SCIENCES LP

14159, L.P.

BAKER BROS ADVISORS LLC

BAKER JULIAN

  • Director
  • 10% Owner
 0 2013-06-07 0

BAKER JULIAN

  • Director
  • 10% Owner
 0 2013-05-30 0

BAKER FELIX

BAKER BROS. INVESTMENTS, L.P.

BAKER BROS. INVESTMENTS II, L.P.

BAKER/TISCH INVESTMENTS, LP

667, L.P.

BAKER BROTHERS LIFE SCIENCES LP

14159, L.P.

  • Director
  • 10% Owner
 12,537,654 2013-01-01 0

BAKER BROS ADVISORS LLC

BAKER FELIX

BAKER JULIAN

  • 10% Owner
 15,621,812 2012-12-12 0

FBB ASSOCIATES

  • Director
 173,897 2012-07-26 0

BAKER BROS. INVESTMENTS, L.P.

  • Director
 173,897 2012-07-26 0

BAKER BROS. INVESTMENTS II, L.P.

  • Director
 13,238 2012-07-26 0

BAKER/TISCH INVESTMENTS, LP

  • Director
 194,161 2012-07-26 0

BAKER BROS ADVISORS LLC

  • 10% Owner
 0 2012-04-12 0

BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC

BAKER FELIX

BAKER JULIAN

  • 10% Owner
 2,328,863 2012-03-12 0

14159 CAPITAL (GP), LLC

BAKER JULIAN

BAKER FELIX

  • 10% Owner
 57,704 2012-03-12 0

BAKER BIOTECH CAPITAL (GP), LLC

BAKER JULIAN

BAKER FELIX

  • 10% Owner
 232,011 2012-03-12 0

BAKER JOFFRE CHIEF SCIENTIFIC OFFICER

  • Officer
 235,302 2012-02-15 0

BAKER BROS. CAPITAL (GP), LLC

BAKER FELIX

BAKER JULIAN

  • 10% Owner
 0 2012-01-27 0

BAKER / TISCH CAPITAL (GP), LLC

BAKER JULIAN

BAKER FELIX

  • Director
  • 10% Owner
 450,461 2011-12-30 0

Insider Transactions Last 60 Days

Reporting Owners Transaction Date Transaction Code Shares Share Price Acquired or Disposed Shares Owned Following Transaction Combined shares owned after filing Direct/Indirect Ownership 10b-5

COLE G BRADLEY - Officer CFO

2019-05-14 M 6,424 d 0 43,722.00 direct

COLE G BRADLEY - Officer CFO held by the cole family trust

2019-05-14 S 1,750 $56.66 d 48,396 43,722.00 indirect

COLE G BRADLEY - Officer CFO held by the cole family trust

2019-05-14 S 1,000 $56.52 d 47,722 43,722.00 indirect

COLE G BRADLEY - Officer CFO

2019-05-14 M 5,000 d 11,471 43,722.00 direct

COLE G BRADLEY - Officer CFO held by the cole family trust

2019-05-14 M 6,424 $22.98 a 50,146 43,722.00 indirect

COLE G BRADLEY - Officer CFO held by the cole family trust

2019-05-14 M 5,000 $17.18 a 48,722 43,722.00 indirect

COLE G BRADLEY - Officer CFO held by the cole family trust

2019-05-14 S 4,674 $57.36 d 43,722 43,722.00 indirect

COLE G BRADLEY - Officer CFO held by the cole family trust

2019-05-14 S 4,000 $57.34 d 43,722 43,722.00 indirect

VAUGHN JAMES J - Officer CHIEF COMMERCIAL OFFICER

2019-05-08 M 1,500 $31.12 a 27,664 20,420.00 direct

SHAK STEVEN - Officer CHIEF SCIENTIFIC OFFICER held by the shak family trust

2019-05-08 S 6,500 $58.84 d 233,579 233,479.00 indirect

VAUGHN JAMES J - Officer CHIEF COMMERCIAL OFFICER

2019-05-08 M 1,500 d 15,397 20,420.00 direct

VAUGHN JAMES J - Officer CHIEF COMMERCIAL OFFICER

2019-05-08 S 1,044 $57.82 d 21,420 20,420.00 direct

VAUGHN JAMES J - Officer CHIEF COMMERCIAL OFFICER

2019-05-08 S 542 $57.73 d 23,764 20,420.00 direct

VAUGHN JAMES J - Officer CHIEF COMMERCIAL OFFICER

2019-05-08 S 1,258 $57.89 d 25,806 20,420.00 direct

VAUGHN JAMES J - Officer CHIEF COMMERCIAL OFFICER

2019-05-08 M 3,000 $31.12 a 26,164 20,420.00 direct

SHAK STEVEN - Officer CHIEF SCIENTIFIC OFFICER held by the shak family trust

2019-05-08 S 15,300 $57.68 d 240,079 233,479.00 indirect

VAUGHN JAMES J - Officer CHIEF COMMERCIAL OFFICER

2019-05-08 M 3,000 d 16,897 20,420.00 direct

VAUGHN JAMES J - Officer CHIEF COMMERCIAL OFFICER

2019-05-08 S 700 $57.15 d 22,464 20,420.00 direct

VAUGHN JAMES J - Officer CHIEF COMMERCIAL OFFICER

2019-05-08 S 358 $57.15 d 24,306 20,420.00 direct

VAUGHN JAMES J - Officer CHIEF COMMERCIAL OFFICER

2019-05-08 S 600 $57.08 d 27,064 20,420.00 direct

SHAK STEVEN - Officer CHIEF SCIENTIFIC OFFICER held by the shak family trust

2019-05-08 S 100 $59.59 d 233,479 233,479.00 indirect

SHAK STEVEN - Officer CHIEF SCIENTIFIC OFFICER held by the shak family trust

2019-05-08 S 3,100 $56.97 d 255,379 233,479.00 indirect

VAUGHN JAMES J - Officer CHIEF COMMERCIAL OFFICER

2019-05-08 S 1,000 $58.94 d 20,420 20,420.00 direct

VAUGHN JAMES J - Officer CHIEF COMMERCIAL OFFICER

2019-05-08 S 600 $58.86 d 23,164 20,420.00 direct

VAUGHN JAMES J - Officer CHIEF COMMERCIAL OFFICER

2019-05-08 S 1,142 $58.91 d 24,664 20,420.00 direct

FLANNELLY BARRY P - Director

2019-04-16 A 20,000 a 20,000 0.00 direct

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-12 S 158 $65.32 d 171,091 9,648,204.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-12 S 63,775 $67.13 d 7,648,570 38,896,983.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-12 S 979 $67.13 d 157,661 38,896,983.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-12 S 173,085 $64.62 d 7,712,345 38,896,983.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-12 S 2,656 $64.62 d 158,640 38,896,983.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-12 S 9,232 $65.32 d 7,639,338 9,648,204.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-12 S 142 $65.32 d 157,519 9,648,204.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-12 S 9,791 $67.13 d 1,215,992 38,896,983.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-12 S 74 $67.13 d 49,904 38,896,983.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-12 S 26,575 $64.62 d 1,225,783 38,896,983.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-12 S 202 $64.62 d 49,978 38,896,983.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-12 S 1,417 $65.32 d 1,214,575 9,648,204.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-12 S 11 $65.32 d 49,893 9,648,204.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-12 S 1,688 $67.13 d 242,135 38,896,983.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-12 S 1,093 $67.13 d 171,249 38,896,983.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-12 S 4,581 $64.62 d 243,823 38,896,983.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-12 S 2,966 $64.62 d 172,342 38,896,983.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-12 S 244 $65.32 d 241,891 9,648,204.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-11 S 106,054 $66.61 d 7,885,430 38,896,983.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-11 S 1,628 $66.61 d 161,296 38,896,983.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-11 S 60,618 $67.42 d 7,991,484 38,896,983.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-11 S 930 $67.42 d 162,924 38,896,983.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-11 S 16,282 $66.61 d 1,252,358 38,896,983.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-11 S 124 $66.61 d 50,180 38,896,983.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-11 S 9,307 $67.42 d 1,268,640 38,896,983.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-11 S 71 $67.42 d 50,304 38,896,983.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-11 S 2,807 $66.61 d 248,404 38,896,983.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-11 S 1,817 $66.61 d 175,308 38,896,983.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-11 S 1,604 $67.42 d 251,211 38,896,983.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-11 S 1,039 $67.42 d 177,125 38,896,983.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-10 S 10,832 $69.12 d 8,052,102 10,149,154.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-10 S 166 $69.12 d 163,854 10,149,154.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-10 S 15,755 $68.70 d 1,279,610 40,541,061.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-10 S 120 $68.70 d 50,388 40,541,061.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-10 S 1,663 $69.12 d 1,277,947 10,149,154.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-10 S 13 $69.12 d 50,375 10,149,154.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-10 S 2,716 $68.70 d 253,102 40,541,061.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-10 S 1,758 $68.70 d 178,349 40,541,061.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-10 S 287 $69.12 d 252,815 10,149,154.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-10 S 185 $69.12 d 178,164 10,149,154.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-10 S 102,618 $68.70 d 8,062,934 40,541,061.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-10 S 1,575 $68.70 d 164,020 40,541,061.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-09 S 28 $67.87 d 165,834 40,541,061.00 indirect

COLE G BRADLEY - Officer CFO held by the cole family trust

2019-04-09 S 300 $68.07 d 43,722 43,722.00 indirect

COLE G BRADLEY - Officer CFO held by the cole family trust

2019-04-09 S 4,896 $67.60 d 53,826 43,722.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-09 S 2,386 $67.68 d 1,295,365 40,541,061.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-09 S 18 $67.68 d 50,508 40,541,061.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-09 S 278 $67.87 d 1,297,751 40,541,061.00 indirect

COLE G BRADLEY - Officer CFO

2019-04-09 M 10,000 d 6,424 43,722.00 direct

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-09 S 2 $67.87 d 50,526 40,541,061.00 indirect

COLE G BRADLEY - Officer CFO held by the cole family trust

2019-04-09 S 9,700 $67.59 d 44,022 43,722.00 indirect

COLE G BRADLEY - Officer CFO held by the cole family trust

2019-04-09 M 10,000 $22.98 a 58,722 43,722.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-09 S 411 $67.68 d 255,818 40,541,061.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-09 S 266 $67.68 d 180,107 40,541,061.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-09 S 48 $67.87 d 256,229 40,541,061.00 indirect

COLE G BRADLEY - Officer CFO

2019-04-09 M 5,000 d 16,471 43,722.00 direct

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-09 S 31 $67.87 d 180,373 40,541,061.00 indirect

COLE G BRADLEY - Officer CFO held by the cole family trust

2019-04-09 S 104 $68.07 d 53,722 43,722.00 indirect

COLE G BRADLEY - Officer CFO held by the cole family trust

2019-04-09 M 5,000 $17.18 a 48,722 43,722.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-09 S 15,543 $67.68 d 8,165,552 40,541,061.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-09 S 239 $67.68 d 165,595 40,541,061.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-09 S 1,813 $67.87 d 8,181,095 40,541,061.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-08 S 18,661 $67.90 d 8,182,908 40,541,061.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-08 S 286 $67.90 d 165,862 40,541,061.00 indirect

POPOVITS KIMBERLY J - Director - Officer PRESIDENT AND CEO held by the popovits 2010 trust

2019-04-08 S 100 $68.31 d 108,952 157,418.00 indirect

VAUGHN JAMES J - Officer CHIEF COMMERCIAL OFFICER

2019-04-08 S 962 $67.18 d 25,202 23,164.00 direct

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-08 S 2,865 $67.90 d 1,298,029 40,541,061.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-08 S 22 $67.90 d 50,528 40,541,061.00 indirect

POPOVITS KIMBERLY J - Director - Officer PRESIDENT AND CEO held by the popovits 2010 trust

2019-04-08 S 2,364 $67.55 d 109,052 157,418.00 indirect

VAUGHN JAMES J - Officer CHIEF COMMERCIAL OFFICER

2019-04-08 M 3,000 d 19,897 23,164.00 direct

VAUGHN JAMES J - Officer CHIEF COMMERCIAL OFFICER

2019-04-08 M 3,000 $31.12 a 26,164 23,164.00 direct

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-08 S 494 $67.90 d 256,277 40,541,061.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-08 S 320 $67.90 d 180,404 40,541,061.00 indirect

POPOVITS KIMBERLY J - Director - Officer PRESIDENT AND CEO held by the popovits 2010 trust

2019-04-08 S 7,536 $66.72 d 111,416 157,418.00 indirect

VAUGHN JAMES J - Officer CHIEF COMMERCIAL OFFICER

2019-04-08 S 2,038 $67.98 d 23,164 23,164.00 direct

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-05 S 42,863 $68.72 d 8,201,569 41,088,890.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-05 S 658 $68.72 d 166,148 41,088,890.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-05 S 21,116 $68.63 d 8,244,432 41,088,890.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-05 S 324 $68.63 d 166,806 41,088,890.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-05 S 6,581 $68.72 d 1,300,894 41,088,890.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-05 S 50 $68.72 d 50,550 41,088,890.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-05 S 3,242 $68.63 d 1,307,475 41,088,890.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-05 S 25 $68.63 d 50,600 41,088,890.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-05 S 1,134 $68.72 d 256,771 41,088,890.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-05 S 734 $68.72 d 180,724 41,088,890.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-05 S 559 $68.63 d 257,905 41,088,890.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-05 S 362 $68.63 d 181,458 41,088,890.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-04 S 1,145 $66.64 d 181,820 41,088,890.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-04 S 66,784 $66.64 d 8,265,548 41,088,890.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-04 S 1,025 $66.64 d 167,130 41,088,890.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-04 S 10,253 $66.64 d 1,310,717 41,088,890.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-04 S 78 $66.64 d 50,625 41,088,890.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-04 S 1,768 $66.64 d 258,464 41,088,890.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-03 S 2,121 $68.90 d 260,232 41,088,890.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-03 S 1,374 $68.90 d 182,965 41,088,890.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-03 S 80,146 $68.90 d 8,332,332 41,088,890.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-03 S 1,230 $68.90 d 168,155 41,088,890.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-03 S 12,305 $68.90 d 1,320,970 41,088,890.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-04-03 S 93 $68.90 d 50,703 41,088,890.00 indirect

GRAHAM GINGER L - Director held by the ginger l. graham revocable trust

2019-04-01 A 149 $66.84 a 51,952 51,952.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

2019-04-01 A 298 $66.84 a 262,353 10,586,523.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

2019-04-01 A 298 $66.84 a 184,339 10,586,523.00 indirect

SHAK STEVEN - Officer CHIEF SCIENTIFIC OFFICER held by the shak family trust

2019-04-01 S 2,100 $69.12 d 259,579 258,479.00 indirect

FUCHS HENRY J - Director

2019-04-01 A 149 $66.84 a 6,481 6,481.00 direct

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

2019-04-01 A 298 $66.84 a 8,412,478 10,586,523.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

2019-04-01 A 298 $66.84 a 169,385 10,586,523.00 indirect

SHAK STEVEN - Officer CHIEF SCIENTIFIC OFFICER held by the shak family trust

2019-04-01 S 300 $70.95 d 258,479 258,479.00 indirect

SHAK STEVEN - Officer CHIEF SCIENTIFIC OFFICER held by the shak family trust

2019-04-01 S 11,279 $68.05 d 261,679 258,479.00 indirect

COHEN FRED E - Director

2019-04-01 A 149 $66.84 a 67,768 73,836.00 direct

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

2019-04-01 A 298 $66.84 a 1,333,275 10,586,523.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

2019-04-01 A 298 $66.84 a 50,796 10,586,523.00 indirect

SHAK STEVEN - Officer CHIEF SCIENTIFIC OFFICER held by the shak family trust

2019-04-01 S 800 $69.80 d 258,779 258,479.00 indirect

SHAK STEVEN - Officer CHIEF SCIENTIFIC OFFICER held by the shak family trust

2019-04-01 S 10,521 $66.94 d 272,958 258,479.00 indirect

POPOVITS KIMBERLY J - Director - Officer PRESIDENT AND CEO held by the popovits 2010 trust

2019-03-29 G 7,000 d 118,952 157,418.00 indirect

SHAK STEVEN - Officer CHIEF SCIENTIFIC OFFICER held by the shak family trust

2019-03-29 S 100 $70.49 d 283,479 258,479.00 indirect

SHAK STEVEN - Officer CHIEF SCIENTIFIC OFFICER held by the shak family trust

2019-03-29 S 10,528 $69.84 d 283,579 258,479.00 indirect

SHAK STEVEN - Officer CHIEF SCIENTIFIC OFFICER held by the shak family trust

2019-03-29 S 14,372 $69.03 d 294,107 258,479.00 indirect

SHAK STEVEN - Officer CHIEF SCIENTIFIC OFFICER held by the shak family trust

2019-03-28 S 108 $69.67 d 308,479 258,479.00 indirect

SHAK STEVEN - Officer CHIEF SCIENTIFIC OFFICER held by the shak family trust

2019-03-28 S 10,272 $68.97 d 308,587 258,479.00 indirect

SHAK STEVEN - Officer CHIEF SCIENTIFIC OFFICER held by the shak family trust

2019-03-28 S 14,620 $68.21 d 318,859 258,479.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-03-21 S 800 $74.71 d 184,041 10,584,735.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-03-21 S 46,678 $74.71 d 8,412,180 10,584,735.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-03-21 S 716 $74.71 d 169,087 10,584,735.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-03-21 S 7,167 $74.71 d 1,332,977 10,584,735.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-03-21 S 55 $74.71 d 50,498 10,584,735.00 indirect

BAKER BROS. ADVISORS LP - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS, L.P. - Director - > 10% Owner see footnotes

BAKER/TISCH INVESTMENTS, LP - Director - > 10% Owner see footnotes

14159, L.P. - Director - > 10% Owner see footnotes

667, L.P. - Director - > 10% Owner see footnotes

BAKER BROS. ADVISORS (GP) LLC - Director - > 10% Owner see footnotes

BAKER BROTHERS LIFE SCIENCES LP - Director - > 10% Owner see footnotes

BAKER FELIX - Director - > 10% Owner see footnotes

BAKER JULIAN - Director - > 10% Owner see footnotes

BAKER BROS. INVESTMENTS II, L.P. - Director - > 10% Owner see footnotes

2019-03-21 S 1,235 $74.71 d 262,055 10,584,735.00 indirect
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