Ionis Pharmaceuticals Inc (IONS)

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Sector:	HEALTH CARE
Industry:	PHARMACEUTICALS
SIC:	PHARMACEUTICAL PREPARATIONS
CEO:	Brett P. Monia
Employees:	800
Web site:	ionispharma.com
2855 GAZELLE COURT, CARLSBAD, CA, 92010 7609319200

Isis Pharmaceuticals, Inc

	All 13F Filers	Prior	Change	Hedge Funds ¹	Prior	Change

Ionis Pharmaceuticals, Inc. discovers and develops RNA-targeted therapeutics in the United States. The company offers SPINRAZA for spinal muscular atrophy (SMA) in pediatric and adult patients; TEGSEDI, an injection for the treatment of polyneuropathy of hereditary transthyretin-mediated amyloidosis in adults; WAYLIVRA, a treatment for familial chylomicronemia syndrome and familial partial lipodystrophy.

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Investor	History	Shares Held or Principal Amt	Market Value	% of Portfolio	Previous % of Portfolio	Rank	Change in Shares	% Change in Shares	% Ownership	Qtr 1st Owned	Est. Avg Price	Source	Source Date	Date Reported
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