iTeos Therapeutics, Inc. (ITOS)

Sector:
HEALTH CARE
Industry:
PHARMACEUTICALS
SIC:
BIOLOGICAL PRODUCTS, (NO DISGNOSTIC SUBSTANCES)
CEO:
Michel Detheux
Employees:
46
139 MAIN STREET, CAMBRIDGE, MA 02142
857-204-4583

We are a clinical-stage biopharmaceutical company pioneering the discovery and development of a new generation of highly differentiated immuno-oncology therapeutics for patients. We leverage our deep understanding of the tumor microenvironment and immunosuppressive pathways to design novel product candidates with an aim to improve the clinical benefit of oncology therapies.

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Funds Holding ITOS (via 13F filings)

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*Please note that if a filer hasn't submitted a 13F filing for a quarter then the filer's shares will be listed as "Sold All"

Mutual Funds Holding ITOS BETA

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Open Market Buys/Sells Last 60 Days

Open Market Buys (P)

none

Open Market Sells (S)

2.3 Million total shares from 125 transactions

Exercise Derivative Conversion (M)

145.3 Thousand total shares from 11 transactions

Current/Former Insiders

Insider Name Type Last Reported Shares Held Last Reported Date Filings in past year

GADICKE ANSBERT

UBS ONCOLOGY IMPACT FUND L.P.

BIOIMPACT CAPITAL LLC

ONCOLOGY IMPACT FUND (CAYMAN) MANAGEMENT L.P.

  • 10% Owner
4,484,728 2022-01-04 18

MPM BIOVENTURES 2014, L.P.

EVNIN LUKE

FOLEY TODD

MPM BIOVENTURES 2014 (B), L.P.

MPM ASSET MANAGEMENT INVESTORS BV2014 LLC

MPM BIOVENTURES 2014 LLC

MPM BIOVENTURES 2014 GP LLC

MPM BIOVENTURES 2018 (B), L.P.

MPM ASSET MANAGEMENT INVESTORS BV2018 LLC

  • 10% Owner
2,738,785 2022-01-04 18

MPM BIOVENTURES 2018, L.P.

MPM BIOVENTURES 2018 LLC

MPM BIOVENTURES 2018 GP LLC

  • 10% Owner
2,738,785 2022-01-04 18

BOXER CAPITAL, LLC

BOXER ASSET MANAGEMENT INC.

LEWIS JOSEPH

MVA INVESTORS, LLC

DAVIS AARON I.

  • Director
  • 10% Owner
7,619,195 2022-01-03 1

LAGER JOANNE JENKINS CHIEF MEDICAL OFFICER

  • Officer
189,438 2022-01-03 6

BINISZKIEWICZ DETLEV

  • Director
13,108 2022-01-03 2

GALL MATTHEW CHIEF FINANCIAL OFFICER

  • Officer
14,429 2021-12-27 5

HALLAL DAVID

  • Director
151,721 2021-12-20 2

DETHEUX MICHEL CHIEF EXECUTIVE OFFICER

  • Officer
229,900 2021-12-02 11

CALL MATTHEW CHIEF OPERATING OFFICER

  • Officer
201,762 2021-07-30 3

RHOADS ANN D

  • Director
16,608 2021-06-17 1

DAVIS AARON I.

  • Director
16,608 2021-06-17 1

HO TONY W

  • Director
4,560 2021-06-17 3

IANNONE ROBERT

  • Director
4,560 2021-06-17 3

DIROCCO DEREK

  • Director
0 2021-06-17 1

VAN HAUWERMEIREN TIMOTHY

  • Director
0 2021-06-17 1

RODEN MATTHEW

  • Director
0 2021-06-17 1

MCGRATH YVONNE VP, RESEARCH AND DEVELOPMENT

  • Officer
95,123 2021-06-08 6

GADICKE ANSBERT

UBS ONCOLOGY IMPACT FUND L.P.

MPM ONCOLOGY IMPACT MANAGEMENT LP

ONCOLOGY IMPACT FUND (CAYMAN) MANAGEMENT L.P.

MPM ONCOLOGY IMPACT MANAGEMENT GP LLC

  • 10% Owner
6,004,368 2021-04-09 18

RA CAPITAL MANAGEMENT, L.P.

RA CAPITAL HEALTHCARE FUND LP

KOLCHINSKY PETER

SHAH RAJEEV M.

  • Director
  • 10% Owner
4,417,259 2021-04-01 1

BOXER CAPITAL, LLC

BOXER ASSET MANAGEMENT INC.

LEWIS JOSEPH

MVA INVESTORS, LLC

  • 10% Owner
7,409,518 2020-07-28 0

MPM BIOVENTURES 2014, L.P.

EVNIN LUKE

FOLEY TODD

MPM BIOVENTURES 2014 (B), L.P.

MPM ASSET MANAGEMENT INVESTORS BV2014 LLC

MPM BIOVENTURES 2014 LLC

MPM BIOVENTURES 2014 GP LLC

MPM BIOVENTURES 2018, L.P.

MPM BIOVENTURES 2018 (B), L.P.

MPM ASSET MANAGEMENT INVESTORS BV2018 LLC

  • 10% Owner
3,799,897 2020-07-28 0

RA CAPITAL MANAGEMENT, L.P.

KOLCHINSKY PETER

SHAH RAJEEV M.

  • 10% Owner
4,417,259 2020-07-28 0

MPM BIOVENTURES 2014, L.P.

MPM BIOVENTURES 2018 LLC

MPM BIOVENTURES 2018 GP LLC

  • 10% Owner
3,799,897 2020-07-28 0

GADICKE ANSBERT

  • Director
  • 10% Owner
0 2020-07-23 18

BELAWAT PRIYANKA

  • Director
0 2020-07-23 0

Insider Transactions Last 60 Days

Reporting Owners Filing Date Trans Date Trans Code Shares Share Price Acquired
Disposed
Shares Owned after D/I 10b5 Perf 1d* Perf 5d* Perf 1m* Max Gain Max Gain Days Max Loss Max Loss Days

GADICKE ANSBERT - > 10% Owner see footnote

UBS ONCOLOGY IMPACT FUND L.P. - > 10% Owner see footnote

BIOIMPACT CAPITAL LLC - > 10% Owner see footnote

ONCOLOGY IMPACT FUND (CAYMAN) MANAGEMENT L.P. - > 10% Owner see footnote

2022-01-06 16:12:23 -0500 2022-01-05 S 30,347 $42.03 d 4,484,728 indirect -2.8133 -7.7889 0.0 1 -9.2072 5

MPM BIOVENTURES 2014, L.P. - > 10% Owner see footnote

EVNIN LUKE - > 10% Owner see footnote

FOLEY TODD - > 10% Owner see footnote

MPM BIOVENTURES 2014 (B), L.P. - > 10% Owner see footnote

MPM ASSET MANAGEMENT INVESTORS BV2014 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2014 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2014 GP LLC - > 10% Owner see footnote

MPM BIOVENTURES 2018 (B), L.P. - > 10% Owner see footnote

MPM ASSET MANAGEMENT INVESTORS BV2018 LLC - > 10% Owner see footnote

2022-01-06 16:12:58 -0500 2022-01-05 S 18,135 $42.03 d 2,738,785 indirect -2.8133 -7.7889 0.0 1 -9.2072 5

MPM BIOVENTURES 2018, L.P. - > 10% Owner see footnote

MPM BIOVENTURES 2018 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2018 GP LLC - > 10% Owner see footnote

2022-01-06 16:13:37 -0500 2022-01-05 S 18,135 $42.03 d 2,738,785 indirect -2.8133 -7.7889 0.0 1 -9.2072 5

GADICKE ANSBERT - > 10% Owner see footnote

UBS ONCOLOGY IMPACT FUND L.P. - > 10% Owner see footnote

BIOIMPACT CAPITAL LLC - > 10% Owner see footnote

ONCOLOGY IMPACT FUND (CAYMAN) MANAGEMENT L.P. - > 10% Owner see footnote

2022-01-06 16:12:23 -0500 2022-01-04 S 32,396 $43.20 d 4,539,222 indirect -2.8133 -7.7889 0.0 1 -9.2072 5

BOXER CAPITAL, LLC - Director - > 10% Owner

BOXER ASSET MANAGEMENT INC. - > 10% Owner

LEWIS JOSEPH - > 10% Owner

MVA INVESTORS, LLC - > 10% Owner

DAVIS AARON I. - Director

2022-01-05 21:20:13 -0500 2022-01-04 S 2,517 $45.48 d 0 direct 2.5757 -6.8686 2.5757 2 -6.8686 6

MPM BIOVENTURES 2014, L.P. - > 10% Owner see footnote

EVNIN LUKE - > 10% Owner see footnote

FOLEY TODD - > 10% Owner see footnote

MPM BIOVENTURES 2014 (B), L.P. - > 10% Owner see footnote

MPM ASSET MANAGEMENT INVESTORS BV2014 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2014 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2014 GP LLC - > 10% Owner see footnote

MPM BIOVENTURES 2018 (B), L.P. - > 10% Owner see footnote

MPM ASSET MANAGEMENT INVESTORS BV2018 LLC - > 10% Owner see footnote

2022-01-06 16:12:58 -0500 2022-01-04 S 6,768 $45.32 d 2,764,591 indirect -2.8133 -7.7889 0.0 1 -9.2072 5

MPM BIOVENTURES 2018, L.P. - > 10% Owner see footnote

MPM BIOVENTURES 2018 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2018 GP LLC - > 10% Owner see footnote

2022-01-06 16:13:37 -0500 2022-01-04 S 6,768 $45.32 d 2,764,591 indirect -2.8133 -7.7889 0.0 1 -9.2072 5

GADICKE ANSBERT - > 10% Owner see footnote

UBS ONCOLOGY IMPACT FUND L.P. - > 10% Owner see footnote

BIOIMPACT CAPITAL LLC - > 10% Owner see footnote

ONCOLOGY IMPACT FUND (CAYMAN) MANAGEMENT L.P. - > 10% Owner see footnote

2022-01-06 16:12:23 -0500 2022-01-04 S 158,579 $42.05 d 4,571,618 indirect -2.8133 -7.7889 0.0 1 -9.2072 5

BOXER CAPITAL, LLC - Director - > 10% Owner

BOXER ASSET MANAGEMENT INC. - > 10% Owner

LEWIS JOSEPH - > 10% Owner

MVA INVESTORS, LLC - > 10% Owner

DAVIS AARON I. - Director

2022-01-05 21:20:13 -0500 2022-01-04 S 88,054 $41.84 d 3,767,405 direct 2.5757 -6.8686 2.5757 2 -6.8686 6

BOXER CAPITAL, LLC - Director - > 10% Owner

BOXER ASSET MANAGEMENT INC. - > 10% Owner

LEWIS JOSEPH - > 10% Owner

MVA INVESTORS, LLC - > 10% Owner

DAVIS AARON I. - Director

2022-01-05 21:20:13 -0500 2022-01-04 S 7,483 $45.48 d 3,717,259 direct 2.5757 -6.8686 2.5757 2 -6.8686 6

BOXER CAPITAL, LLC - Director - > 10% Owner

BOXER ASSET MANAGEMENT INC. - > 10% Owner

LEWIS JOSEPH - > 10% Owner

MVA INVESTORS, LLC - > 10% Owner

DAVIS AARON I. - Director

2022-01-05 21:20:13 -0500 2022-01-04 S 11,199 $44.44 d 2,517 direct 2.5757 -6.8686 2.5757 2 -6.8686 6

GADICKE ANSBERT - > 10% Owner see footnote

UBS ONCOLOGY IMPACT FUND L.P. - > 10% Owner see footnote

BIOIMPACT CAPITAL LLC - > 10% Owner see footnote

ONCOLOGY IMPACT FUND (CAYMAN) MANAGEMENT L.P. - > 10% Owner see footnote

2022-01-06 16:12:23 -0500 2022-01-04 S 12,829 $46.47 d 4,515,075 indirect -2.8133 -7.7889 0.0 1 -9.2072 5

MPM BIOVENTURES 2014, L.P. - > 10% Owner see footnote

EVNIN LUKE - > 10% Owner see footnote

FOLEY TODD - > 10% Owner see footnote

MPM BIOVENTURES 2014 (B), L.P. - > 10% Owner see footnote

MPM ASSET MANAGEMENT INVESTORS BV2014 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2014 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2014 GP LLC - > 10% Owner see footnote

MPM BIOVENTURES 2018 (B), L.P. - > 10% Owner see footnote

MPM ASSET MANAGEMENT INVESTORS BV2018 LLC - > 10% Owner see footnote

2022-01-06 16:12:58 -0500 2022-01-04 S 19,366 $43.20 d 2,771,359 indirect -2.8133 -7.7889 0.0 1 -9.2072 5

MPM BIOVENTURES 2018, L.P. - > 10% Owner see footnote

MPM BIOVENTURES 2018 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2018 GP LLC - > 10% Owner see footnote

2022-01-06 16:13:37 -0500 2022-01-04 S 19,366 $43.20 d 2,771,359 indirect -2.8133 -7.7889 0.0 1 -9.2072 5

BOXER CAPITAL, LLC - Director - > 10% Owner

BOXER ASSET MANAGEMENT INC. - > 10% Owner

LEWIS JOSEPH - > 10% Owner

MVA INVESTORS, LLC - > 10% Owner

DAVIS AARON I. - Director

2022-01-05 21:20:13 -0500 2022-01-04 S 33,297 $44.44 d 3,724,742 direct 2.5757 -6.8686 2.5757 2 -6.8686 6

BOXER CAPITAL, LLC - Director - > 10% Owner

BOXER ASSET MANAGEMENT INC. - > 10% Owner

LEWIS JOSEPH - > 10% Owner

MVA INVESTORS, LLC - > 10% Owner

DAVIS AARON I. - Director

2022-01-05 21:20:13 -0500 2022-01-04 S 3,138 $43.36 d 13,716 direct 2.5757 -6.8686 2.5757 2 -6.8686 6

GADICKE ANSBERT - > 10% Owner see footnote

UBS ONCOLOGY IMPACT FUND L.P. - > 10% Owner see footnote

BIOIMPACT CAPITAL LLC - > 10% Owner see footnote

ONCOLOGY IMPACT FUND (CAYMAN) MANAGEMENT L.P. - > 10% Owner see footnote

2022-01-06 16:12:23 -0500 2022-01-04 S 11,318 $45.32 d 4,527,904 indirect -2.8133 -7.7889 0.0 1 -9.2072 5

MPM BIOVENTURES 2014, L.P. - > 10% Owner see footnote

EVNIN LUKE - > 10% Owner see footnote

FOLEY TODD - > 10% Owner see footnote

MPM BIOVENTURES 2014 (B), L.P. - > 10% Owner see footnote

MPM ASSET MANAGEMENT INVESTORS BV2014 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2014 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2014 GP LLC - > 10% Owner see footnote

MPM BIOVENTURES 2018 (B), L.P. - > 10% Owner see footnote

MPM ASSET MANAGEMENT INVESTORS BV2018 LLC - > 10% Owner see footnote

2022-01-06 16:12:58 -0500 2022-01-04 S 94,745 $42.05 d 2,790,725 indirect -2.8133 -7.7889 0.0 1 -9.2072 5

MPM BIOVENTURES 2018, L.P. - > 10% Owner see footnote

MPM BIOVENTURES 2018 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2018 GP LLC - > 10% Owner see footnote

2022-01-06 16:13:37 -0500 2022-01-04 S 94,745 $42.05 d 2,790,725 indirect -2.8133 -7.7889 0.0 1 -9.2072 5

MPM BIOVENTURES 2014, L.P. - > 10% Owner see footnote

EVNIN LUKE - > 10% Owner see footnote

FOLEY TODD - > 10% Owner see footnote

MPM BIOVENTURES 2014 (B), L.P. - > 10% Owner see footnote

MPM ASSET MANAGEMENT INVESTORS BV2014 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2014 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2014 GP LLC - > 10% Owner see footnote

MPM BIOVENTURES 2018 (B), L.P. - > 10% Owner see footnote

MPM ASSET MANAGEMENT INVESTORS BV2018 LLC - > 10% Owner see footnote

2022-01-06 16:12:58 -0500 2022-01-04 S 7,671 $46.47 d 2,756,920 indirect -2.8133 -7.7889 0.0 1 -9.2072 5

MPM BIOVENTURES 2018, L.P. - > 10% Owner see footnote

MPM BIOVENTURES 2018 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2018 GP LLC - > 10% Owner see footnote

2022-01-06 16:13:37 -0500 2022-01-04 S 7,671 $46.47 d 2,756,920 indirect -2.8133 -7.7889 0.0 1 -9.2072 5

BOXER CAPITAL, LLC - Director - > 10% Owner

BOXER ASSET MANAGEMENT INC. - > 10% Owner

LEWIS JOSEPH - > 10% Owner

MVA INVESTORS, LLC - > 10% Owner

DAVIS AARON I. - Director

2022-01-05 21:20:13 -0500 2022-01-04 S 9,366 $43.36 d 3,758,039 direct 2.5757 -6.8686 2.5757 2 -6.8686 6

BOXER CAPITAL, LLC - Director - > 10% Owner

BOXER ASSET MANAGEMENT INC. - > 10% Owner

LEWIS JOSEPH - > 10% Owner

MVA INVESTORS, LLC - > 10% Owner

DAVIS AARON I. - Director

2022-01-05 21:20:13 -0500 2022-01-04 S 29,623 $41.84 d 16,854 direct 2.5757 -6.8686 2.5757 2 -6.8686 6

BINISZKIEWICZ DETLEV - Director

2022-01-04 21:41:35 -0500 2022-01-03 M 3,500 $19.00 a 3,500 direct -0.0715 -2.5977 2.5024 3 -2.5977 6

BOXER CAPITAL, LLC - Director - > 10% Owner

BOXER ASSET MANAGEMENT INC. - > 10% Owner

LEWIS JOSEPH - > 10% Owner

MVA INVESTORS, LLC - > 10% Owner

DAVIS AARON I. - Director

2022-01-05 21:20:13 -0500 2022-01-03 S 432,903 $47.65 d 3,912,113 direct 2.5757 -6.8686 2.5757 2 -6.8686 6

BOXER CAPITAL, LLC - Director - > 10% Owner

BOXER ASSET MANAGEMENT INC. - > 10% Owner

LEWIS JOSEPH - > 10% Owner

MVA INVESTORS, LLC - > 10% Owner

DAVIS AARON I. - Director

2022-01-05 21:20:13 -0500 2022-01-03 S 23,353 $47.63 d 48,890 direct 2.5757 -6.8686 2.5757 2 -6.8686 6

LAGER JOANNE JENKINS - Officer CHIEF MEDICAL OFFICER

2022-01-04 21:42:15 -0500 2022-01-03 M 7,000 d 189,438 direct yes

BINISZKIEWICZ DETLEV - Director

2022-01-04 21:41:35 -0500 2022-01-03 M 3,500 d 13,108 direct yes

BOXER CAPITAL, LLC - Director - > 10% Owner

BOXER ASSET MANAGEMENT INC. - > 10% Owner

LEWIS JOSEPH - > 10% Owner

MVA INVESTORS, LLC - > 10% Owner

DAVIS AARON I. - Director

2022-01-05 21:20:13 -0500 2022-01-03 S 17,173 $50.63 d 3,855,459 direct 2.5757 -6.8686 2.5757 2 -6.8686 6

BOXER CAPITAL, LLC - Director - > 10% Owner

BOXER ASSET MANAGEMENT INC. - > 10% Owner

LEWIS JOSEPH - > 10% Owner

MVA INVESTORS, LLC - > 10% Owner

DAVIS AARON I. - Director

2022-01-05 21:20:13 -0500 2022-01-03 S 731 $50.63 d 46,477 direct 2.5757 -6.8686 2.5757 2 -6.8686 6

LAGER JOANNE JENKINS - Officer CHIEF MEDICAL OFFICER

2022-01-04 21:42:15 -0500 2022-01-03 S 7,000 $51.90 d 0 direct -0.0715 -2.5977 2.5024 3 -2.5977 6

BINISZKIEWICZ DETLEV - Director

2022-01-04 21:41:35 -0500 2022-01-03 S 3,500 $51.90 d 0 direct -0.0715 -2.5977 2.5024 3 -2.5977 6

BOXER CAPITAL, LLC - Director - > 10% Owner

BOXER ASSET MANAGEMENT INC. - > 10% Owner

LEWIS JOSEPH - > 10% Owner

MVA INVESTORS, LLC - > 10% Owner

DAVIS AARON I. - Director

2022-01-05 21:20:13 -0500 2022-01-03 S 39,481 $49.37 d 3,872,632 direct 2.5757 -6.8686 2.5757 2 -6.8686 6

BOXER CAPITAL, LLC - Director - > 10% Owner

BOXER ASSET MANAGEMENT INC. - > 10% Owner

LEWIS JOSEPH - > 10% Owner

MVA INVESTORS, LLC - > 10% Owner

DAVIS AARON I. - Director

2022-01-05 21:20:13 -0500 2022-01-03 S 1,682 $49.37 d 47,208 direct 2.5757 -6.8686 2.5757 2 -6.8686 6

LAGER JOANNE JENKINS - Officer CHIEF MEDICAL OFFICER

2022-01-04 21:42:15 -0500 2022-01-03 M 7,000 $4.30 a 7,000 direct -0.0715 -2.5977 2.5024 3 -2.5977 6

GALL MATTHEW - Officer CHIEF FINANCIAL OFFICER

2021-12-28 20:58:24 -0500 2021-12-27 S 5,000 $46.45 d 14,429 direct 3.6016 -8.9607 3.6016 2 -8.9607 6

DETHEUX MICHEL - Officer CHIEF EXECUTIVE OFFICER

2021-12-22 20:01:53 -0500 2021-12-22 S 149 $44.92 d 78,200 direct -0.5115 -0.7673 2.0034 3 -1.769 4

DETHEUX MICHEL - Officer CHIEF EXECUTIVE OFFICER

2021-12-22 20:01:53 -0500 2021-12-22 M 1,663 d 60,000 direct yes

DETHEUX MICHEL - Officer CHIEF EXECUTIVE OFFICER

2021-12-22 20:01:53 -0500 2021-12-22 S 1,514 $44.31 d 78,349 direct -0.5115 -0.7673 2.0034 3 -1.769 4

DETHEUX MICHEL - Officer CHIEF EXECUTIVE OFFICER

2021-12-22 20:01:53 -0500 2021-12-22 S 9,493 $45.37 d 63,700 direct -0.5115 -0.7673 2.0034 3 -1.769 4

DETHEUX MICHEL - Officer CHIEF EXECUTIVE OFFICER

2021-12-22 20:01:53 -0500 2021-12-22 M 1,663 $4.30 a 79,863 direct -0.5115 -0.7673 2.0034 3 -1.769 4

DETHEUX MICHEL - Officer CHIEF EXECUTIVE OFFICER

2021-12-22 20:01:53 -0500 2021-12-22 S 5,007 $44.62 d 73,193 direct -0.5115 -0.7673 2.0034 3 -1.769 4

DETHEUX MICHEL - Officer CHIEF EXECUTIVE OFFICER

2021-12-22 20:01:53 -0500 2021-12-21 S 5,580 $45.06 d 78,200 direct -0.5115 -0.7673 2.0034 3 -1.769 4

DETHEUX MICHEL - Officer CHIEF EXECUTIVE OFFICER

2021-12-22 20:01:53 -0500 2021-12-21 S 13,646 $44.15 d 83,780 direct -0.5115 -0.7673 2.0034 3 -1.769 4

DETHEUX MICHEL - Officer CHIEF EXECUTIVE OFFICER

2021-12-22 20:01:53 -0500 2021-12-21 M 19,226 $4.30 a 97,426 direct -0.5115 -0.7673 2.0034 3 -1.769 4

DETHEUX MICHEL - Officer CHIEF EXECUTIVE OFFICER

2021-12-22 20:01:53 -0500 2021-12-21 M 19,226 d 61,663 direct yes

HALLAL DAVID - Director

2021-12-22 19:59:57 -0500 2021-12-20 M 20,000 $4.30 a 20,000 direct -0.5115 -0.7673 2.0034 3 -1.769 4

HALLAL DAVID - Director

2021-12-22 19:59:57 -0500 2021-12-20 M 20,000 d 114,682 direct

DETHEUX MICHEL - Officer CHIEF EXECUTIVE OFFICER

2021-12-22 20:01:53 -0500 2021-12-20 S 9,111 $43.94 d 78,200 direct -0.5115 -0.7673 2.0034 3 -1.769 4

DETHEUX MICHEL - Officer CHIEF EXECUTIVE OFFICER

2021-12-22 20:01:53 -0500 2021-12-20 M 9,111 d 80,889 direct yes

HALLAL DAVID - Director

2021-12-22 19:59:57 -0500 2021-12-20 S 50,000 $43.57 d 0 direct -0.5115 -0.7673 2.0034 3 -1.769 4

DETHEUX MICHEL - Officer CHIEF EXECUTIVE OFFICER

2021-12-22 20:01:53 -0500 2021-12-20 M 9,111 $4.30 a 87,311 direct -0.5115 -0.7673 2.0034 3 -1.769 4

HALLAL DAVID - Director

2021-12-22 19:59:57 -0500 2021-12-20 M 30,000 $2.95 a 50,000 direct -0.5115 -0.7673 2.0034 3 -1.769 4

HALLAL DAVID - Director

2021-12-22 19:59:57 -0500 2021-12-20 M 30,000 d 37,039 direct

LAGER JOANNE JENKINS - Officer CHIEF MEDICAL OFFICER

2021-12-17 19:59:02 -0500 2021-12-17 M 7,000 d 196,438 direct yes

LAGER JOANNE JENKINS - Officer CHIEF MEDICAL OFFICER

2021-12-17 19:59:02 -0500 2021-12-17 S 7,000 $41.00 d 0 direct 3.9455 10.4292 10.4292 6 0.0 1

LAGER JOANNE JENKINS - Officer CHIEF MEDICAL OFFICER

2021-12-17 19:59:02 -0500 2021-12-17 M 7,000 $4.30 a 7,000 direct 3.9455 10.4292 10.4292 6 0.0 1

LAGER JOANNE JENKINS - Officer CHIEF MEDICAL OFFICER

2021-12-10 19:59:11 -0500 2021-12-10 M 3,500 d 203,438 direct yes

LAGER JOANNE JENKINS - Officer CHIEF MEDICAL OFFICER

2021-12-10 19:59:11 -0500 2021-12-10 S 3,500 $34.50 d 0 direct yes 0.3234 16.7879 16.7879 6 0.0 1

LAGER JOANNE JENKINS - Officer CHIEF MEDICAL OFFICER

2021-12-10 19:59:11 -0500 2021-12-10 M 3,500 $4.30 a 3,500 direct yes 0.3234 16.7879 16.7879 6 0.0 1

MPM BIOVENTURES 2018, L.P. - > 10% Owner see footnote

MPM BIOVENTURES 2018 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2018 GP LLC - > 10% Owner see footnote

2021-12-07 18:36:44 -0500 2021-12-07 S 1,494 $34.11 d 2,885,470 indirect yes -1.3817 7.3978 7.3978 6 -1.3817 2

GADICKE ANSBERT - > 10% Owner see footnote

UBS ONCOLOGY IMPACT FUND L.P. - > 10% Owner see footnote

BIOIMPACT CAPITAL LLC - > 10% Owner see footnote

ONCOLOGY IMPACT FUND (CAYMAN) MANAGEMENT L.P. - > 10% Owner see footnote

2021-12-07 18:33:54 -0500 2021-12-07 S 30,059 $33.15 d 4,732,696 indirect yes -1.3817 7.3978 7.3978 6 -1.3817 2

MPM BIOVENTURES 2014, L.P. - > 10% Owner see footnote

EVNIN LUKE - > 10% Owner see footnote

FOLEY TODD - > 10% Owner see footnote

MPM BIOVENTURES 2014 (B), L.P. - > 10% Owner see footnote

MPM ASSET MANAGEMENT INVESTORS BV2014 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2014 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2014 GP LLC - > 10% Owner see footnote

MPM BIOVENTURES 2018 (B), L.P. - > 10% Owner see footnote

MPM ASSET MANAGEMENT INVESTORS BV2018 LLC - > 10% Owner see footnote

2021-12-07 18:35:57 -0500 2021-12-07 S 1,494 $34.11 d 2,885,470 indirect yes -1.3817 7.3978 7.3978 6 -1.3817 2

MPM BIOVENTURES 2018, L.P. - > 10% Owner see footnote

MPM BIOVENTURES 2018 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2018 GP LLC - > 10% Owner see footnote

2021-12-07 18:36:44 -0500 2021-12-07 S 17,962 $33.15 d 2,886,964 indirect yes -1.3817 7.3978 7.3978 6 -1.3817 2

MPM BIOVENTURES 2014, L.P. - > 10% Owner see footnote

EVNIN LUKE - > 10% Owner see footnote

FOLEY TODD - > 10% Owner see footnote

MPM BIOVENTURES 2014 (B), L.P. - > 10% Owner see footnote

MPM ASSET MANAGEMENT INVESTORS BV2014 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2014 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2014 GP LLC - > 10% Owner see footnote

MPM BIOVENTURES 2018 (B), L.P. - > 10% Owner see footnote

MPM ASSET MANAGEMENT INVESTORS BV2018 LLC - > 10% Owner see footnote

2021-12-07 18:35:57 -0500 2021-12-07 S 17,962 $33.15 d 2,886,964 indirect yes -1.3817 7.3978 7.3978 6 -1.3817 2

GADICKE ANSBERT - > 10% Owner see footnote

UBS ONCOLOGY IMPACT FUND L.P. - > 10% Owner see footnote

BIOIMPACT CAPITAL LLC - > 10% Owner see footnote

ONCOLOGY IMPACT FUND (CAYMAN) MANAGEMENT L.P. - > 10% Owner see footnote

2021-12-07 18:33:54 -0500 2021-12-07 S 2,499 $34.11 d 4,730,197 indirect yes -1.3817 7.3978 7.3978 6 -1.3817 2

GADICKE ANSBERT - > 10% Owner see footnote

UBS ONCOLOGY IMPACT FUND L.P. - > 10% Owner see footnote

BIOIMPACT CAPITAL LLC - > 10% Owner see footnote

ONCOLOGY IMPACT FUND (CAYMAN) MANAGEMENT L.P. - > 10% Owner see footnote

2021-12-07 18:33:54 -0500 2021-12-06 S 1,960 $33.57 d 4,763,705 indirect yes -1.3817 7.3978 7.3978 6 -1.3817 2

MPM BIOVENTURES 2014, L.P. - > 10% Owner see footnote

EVNIN LUKE - > 10% Owner see footnote

FOLEY TODD - > 10% Owner see footnote

MPM BIOVENTURES 2014 (B), L.P. - > 10% Owner see footnote

MPM ASSET MANAGEMENT INVESTORS BV2014 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2014 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2014 GP LLC - > 10% Owner see footnote

MPM BIOVENTURES 2018 (B), L.P. - > 10% Owner see footnote

MPM ASSET MANAGEMENT INVESTORS BV2018 LLC - > 10% Owner see footnote

2021-12-07 18:35:57 -0500 2021-12-06 S 508 $34.08 d 2,904,986 indirect yes -1.3817 7.3978 7.3978 6 -1.3817 2

MPM BIOVENTURES 2018, L.P. - > 10% Owner see footnote

MPM BIOVENTURES 2018 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2018 GP LLC - > 10% Owner see footnote

2021-12-07 18:36:44 -0500 2021-12-06 S 1,171 $33.57 d 2,905,494 indirect yes -1.3817 7.3978 7.3978 6 -1.3817 2

GADICKE ANSBERT - > 10% Owner see footnote

UBS ONCOLOGY IMPACT FUND L.P. - > 10% Owner see footnote

BIOIMPACT CAPITAL LLC - > 10% Owner see footnote

ONCOLOGY IMPACT FUND (CAYMAN) MANAGEMENT L.P. - > 10% Owner see footnote

2021-12-07 18:33:54 -0500 2021-12-06 S 14,173 $32.35 d 4,765,665 indirect yes -1.3817 7.3978 7.3978 6 -1.3817 2

MPM BIOVENTURES 2014, L.P. - > 10% Owner see footnote

EVNIN LUKE - > 10% Owner see footnote

FOLEY TODD - > 10% Owner see footnote

MPM BIOVENTURES 2014 (B), L.P. - > 10% Owner see footnote

MPM ASSET MANAGEMENT INVESTORS BV2014 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2014 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2014 GP LLC - > 10% Owner see footnote

MPM BIOVENTURES 2018 (B), L.P. - > 10% Owner see footnote

MPM ASSET MANAGEMENT INVESTORS BV2018 LLC - > 10% Owner see footnote

2021-12-07 18:35:57 -0500 2021-12-06 S 1,171 $33.57 d 2,905,494 indirect yes -1.3817 7.3978 7.3978 6 -1.3817 2

GADICKE ANSBERT - > 10% Owner see footnote

UBS ONCOLOGY IMPACT FUND L.P. - > 10% Owner see footnote

BIOIMPACT CAPITAL LLC - > 10% Owner see footnote

ONCOLOGY IMPACT FUND (CAYMAN) MANAGEMENT L.P. - > 10% Owner see footnote

2021-12-07 18:33:54 -0500 2021-12-06 S 100 $35.04 d 4,762,755 indirect yes -1.3817 7.3978 7.3978 6 -1.3817 2

MPM BIOVENTURES 2018, L.P. - > 10% Owner see footnote

MPM BIOVENTURES 2018 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2018 GP LLC - > 10% Owner see footnote

2021-12-07 18:36:44 -0500 2021-12-06 S 8,469 $32.35 d 2,906,665 indirect yes -1.3817 7.3978 7.3978 6 -1.3817 2

MPM BIOVENTURES 2018, L.P. - > 10% Owner see footnote

MPM BIOVENTURES 2018 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2018 GP LLC - > 10% Owner see footnote

2021-12-07 18:36:44 -0500 2021-12-06 S 60 $35.04 d 2,904,926 indirect yes -1.3817 7.3978 7.3978 6 -1.3817 2

MPM BIOVENTURES 2014, L.P. - > 10% Owner see footnote

EVNIN LUKE - > 10% Owner see footnote

FOLEY TODD - > 10% Owner see footnote

MPM BIOVENTURES 2014 (B), L.P. - > 10% Owner see footnote

MPM ASSET MANAGEMENT INVESTORS BV2014 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2014 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2014 GP LLC - > 10% Owner see footnote

MPM BIOVENTURES 2018 (B), L.P. - > 10% Owner see footnote

MPM ASSET MANAGEMENT INVESTORS BV2018 LLC - > 10% Owner see footnote

2021-12-07 18:35:57 -0500 2021-12-06 S 8,469 $32.35 d 2,906,665 indirect yes -1.3817 7.3978 7.3978 6 -1.3817 2

GADICKE ANSBERT - > 10% Owner see footnote

UBS ONCOLOGY IMPACT FUND L.P. - > 10% Owner see footnote

BIOIMPACT CAPITAL LLC - > 10% Owner see footnote

ONCOLOGY IMPACT FUND (CAYMAN) MANAGEMENT L.P. - > 10% Owner see footnote

2021-12-07 18:33:54 -0500 2021-12-06 S 850 $34.08 d 4,762,855 indirect yes -1.3817 7.3978 7.3978 6 -1.3817 2

MPM BIOVENTURES 2014, L.P. - > 10% Owner see footnote

EVNIN LUKE - > 10% Owner see footnote

FOLEY TODD - > 10% Owner see footnote

MPM BIOVENTURES 2014 (B), L.P. - > 10% Owner see footnote

MPM ASSET MANAGEMENT INVESTORS BV2014 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2014 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2014 GP LLC - > 10% Owner see footnote

MPM BIOVENTURES 2018 (B), L.P. - > 10% Owner see footnote

MPM ASSET MANAGEMENT INVESTORS BV2018 LLC - > 10% Owner see footnote

2021-12-07 18:35:57 -0500 2021-12-06 S 60 $35.04 d 2,904,926 indirect yes -1.3817 7.3978 7.3978 6 -1.3817 2

MPM BIOVENTURES 2018, L.P. - > 10% Owner see footnote

MPM BIOVENTURES 2018 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2018 GP LLC - > 10% Owner see footnote

2021-12-07 18:36:44 -0500 2021-12-06 S 508 $34.08 d 2,904,986 indirect yes -1.3817 7.3978 7.3978 6 -1.3817 2

GADICKE ANSBERT - > 10% Owner see footnote

UBS ONCOLOGY IMPACT FUND L.P. - > 10% Owner see footnote

BIOIMPACT CAPITAL LLC - > 10% Owner see footnote

ONCOLOGY IMPACT FUND (CAYMAN) MANAGEMENT L.P. - > 10% Owner see footnote

2021-12-07 18:33:54 -0500 2021-12-03 S 4,047 $35.44 d 4,780,138 indirect yes -1.3817 7.3978 7.3978 6 -1.3817 2

MPM BIOVENTURES 2014, L.P. - > 10% Owner see footnote

EVNIN LUKE - > 10% Owner see footnote

FOLEY TODD - > 10% Owner see footnote

MPM BIOVENTURES 2014 (B), L.P. - > 10% Owner see footnote

MPM ASSET MANAGEMENT INVESTORS BV2014 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2014 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2014 GP LLC - > 10% Owner see footnote

MPM BIOVENTURES 2018 (B), L.P. - > 10% Owner see footnote

MPM ASSET MANAGEMENT INVESTORS BV2018 LLC - > 10% Owner see footnote

2021-12-07 18:35:57 -0500 2021-12-03 S 179 $36.26 d 2,915,134 indirect yes -1.3817 7.3978 7.3978 6 -1.3817 2

MPM BIOVENTURES 2018, L.P. - > 10% Owner see footnote

MPM BIOVENTURES 2018 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2018 GP LLC - > 10% Owner see footnote

2021-12-07 18:36:44 -0500 2021-12-03 S 2,419 $35.44 d 2,915,313 indirect yes -1.3817 7.3978 7.3978 6 -1.3817 2

GADICKE ANSBERT - > 10% Owner see footnote

UBS ONCOLOGY IMPACT FUND L.P. - > 10% Owner see footnote

BIOIMPACT CAPITAL LLC - > 10% Owner see footnote

ONCOLOGY IMPACT FUND (CAYMAN) MANAGEMENT L.P. - > 10% Owner see footnote

2021-12-07 18:33:54 -0500 2021-12-03 S 29,402 $34.68 d 4,784,185 indirect yes -1.3817 7.3978 7.3978 6 -1.3817 2

MPM BIOVENTURES 2014, L.P. - > 10% Owner see footnote

EVNIN LUKE - > 10% Owner see footnote

FOLEY TODD - > 10% Owner see footnote

MPM BIOVENTURES 2014 (B), L.P. - > 10% Owner see footnote

MPM ASSET MANAGEMENT INVESTORS BV2014 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2014 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2014 GP LLC - > 10% Owner see footnote

MPM BIOVENTURES 2018 (B), L.P. - > 10% Owner see footnote

MPM ASSET MANAGEMENT INVESTORS BV2018 LLC - > 10% Owner see footnote

2021-12-07 18:35:57 -0500 2021-12-03 S 2,419 $35.44 d 2,915,313 indirect yes -1.3817 7.3978 7.3978 6 -1.3817 2

MPM BIOVENTURES 2018, L.P. - > 10% Owner see footnote

MPM BIOVENTURES 2018 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2018 GP LLC - > 10% Owner see footnote

2021-12-07 18:36:44 -0500 2021-12-03 S 17,569 $34.68 d 2,917,732 indirect yes -1.3817 7.3978 7.3978 6 -1.3817 2

GADICKE ANSBERT - > 10% Owner see footnote

UBS ONCOLOGY IMPACT FUND L.P. - > 10% Owner see footnote

BIOIMPACT CAPITAL LLC - > 10% Owner see footnote

ONCOLOGY IMPACT FUND (CAYMAN) MANAGEMENT L.P. - > 10% Owner see footnote

2021-12-07 18:33:54 -0500 2021-12-03 S 300 $36.26 d 4,779,838 indirect yes -1.3817 7.3978 7.3978 6 -1.3817 2

MPM BIOVENTURES 2014, L.P. - > 10% Owner see footnote

EVNIN LUKE - > 10% Owner see footnote

FOLEY TODD - > 10% Owner see footnote

MPM BIOVENTURES 2014 (B), L.P. - > 10% Owner see footnote

MPM ASSET MANAGEMENT INVESTORS BV2014 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2014 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2014 GP LLC - > 10% Owner see footnote

MPM BIOVENTURES 2018 (B), L.P. - > 10% Owner see footnote

MPM ASSET MANAGEMENT INVESTORS BV2018 LLC - > 10% Owner see footnote

2021-12-07 18:35:57 -0500 2021-12-03 S 17,569 $34.68 d 2,917,732 indirect yes -1.3817 7.3978 7.3978 6 -1.3817 2

MPM BIOVENTURES 2018, L.P. - > 10% Owner see footnote

MPM BIOVENTURES 2018 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2018 GP LLC - > 10% Owner see footnote

2021-12-07 18:36:44 -0500 2021-12-03 S 179 $36.26 d 2,915,134 indirect yes -1.3817 7.3978 7.3978 6 -1.3817 2

GADICKE ANSBERT - > 10% Owner see footnote

UBS ONCOLOGY IMPACT FUND L.P. - > 10% Owner see footnote

BIOIMPACT CAPITAL LLC - > 10% Owner see footnote

ONCOLOGY IMPACT FUND (CAYMAN) MANAGEMENT L.P. - > 10% Owner see footnote

2021-12-02 18:53:00 -0500 2021-12-02 S 12,434 $34.83 d 4,813,587 indirect yes -7.6393 1.7806 1.7806 6 -7.6393 2

DETHEUX MICHEL - Officer CHIEF EXECUTIVE OFFICER by mg3a

2021-12-22 20:01:53 -0500 2021-12-02 G 313,442 a 313,442 indirect

DETHEUX MICHEL - Officer CHIEF EXECUTIVE OFFICER

2021-12-22 20:01:53 -0500 2021-12-02 G 52,700 d 17,544 direct

MPM BIOVENTURES 2014, L.P. - > 10% Owner see footnote

EVNIN LUKE - > 10% Owner see footnote

FOLEY TODD - > 10% Owner see footnote

MPM BIOVENTURES 2014 (B), L.P. - > 10% Owner see footnote

MPM ASSET MANAGEMENT INVESTORS BV2014 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2014 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2014 GP LLC - > 10% Owner see footnote

MPM BIOVENTURES 2018 (B), L.P. - > 10% Owner see footnote

MPM ASSET MANAGEMENT INVESTORS BV2018 LLC - > 10% Owner see footnote

2021-12-02 18:53:51 -0500 2021-12-02 S 29,757 $33.74 d 2,942,731 indirect yes -7.6393 1.7806 1.7806 6 -7.6393 2

DETHEUX MICHEL - Officer CHIEF EXECUTIVE OFFICER by mg3a

2021-12-22 20:01:53 -0500 2021-12-02 G 776,600 a 776,600 indirect

GADICKE ANSBERT - > 10% Owner see footnote

UBS ONCOLOGY IMPACT FUND L.P. - > 10% Owner see footnote

BIOIMPACT CAPITAL LLC - > 10% Owner see footnote

ONCOLOGY IMPACT FUND (CAYMAN) MANAGEMENT L.P. - > 10% Owner see footnote

2021-12-02 18:53:00 -0500 2021-12-02 S 49,796 $33.74 d 4,826,021 indirect yes -7.6393 1.7806 1.7806 6 -7.6393 2

DETHEUX MICHEL - Officer CHIEF EXECUTIVE OFFICER

2021-12-22 20:01:53 -0500 2021-12-02 G 313,442 d 90,000 direct

DETHEUX MICHEL - Officer CHIEF EXECUTIVE OFFICER by mg3a

2021-12-22 20:01:53 -0500 2021-12-02 G 185,000 a 185,000 indirect

DETHEUX MICHEL - Officer CHIEF EXECUTIVE OFFICER

2021-12-22 20:01:53 -0500 2021-12-02 G 776,600 d 258,824 direct

DETHEUX MICHEL - Officer CHIEF EXECUTIVE OFFICER by mg3a

2021-12-22 20:01:53 -0500 2021-12-02 G 106,200 a 106,200 indirect

MPM BIOVENTURES 2018, L.P. - > 10% Owner see fpotnote

MPM BIOVENTURES 2018 LLC - > 10% Owner see fpotnote

MPM BIOVENTURES 2018 GP LLC - > 10% Owner see fpotnote

2021-12-02 18:56:17 -0500 2021-12-02 S 7,430 $34.83 d 2,935,301 indirect yes -7.6393 1.7806 1.7806 6 -7.6393 2

DETHEUX MICHEL - Officer CHIEF EXECUTIVE OFFICER

2021-12-22 20:01:53 -0500 2021-12-02 G 185,000 d 155,964 direct

DETHEUX MICHEL - Officer CHIEF EXECUTIVE OFFICER by mg3a

2021-12-22 20:01:53 -0500 2021-12-02 G 52,700 a 52,700 indirect

MPM BIOVENTURES 2014, L.P. - > 10% Owner see fpotnote

EVNIN LUKE - > 10% Owner see fpotnote

FOLEY TODD - > 10% Owner see fpotnote

MPM BIOVENTURES 2014 (B), L.P. - > 10% Owner see fpotnote

MPM ASSET MANAGEMENT INVESTORS BV2014 LLC - > 10% Owner see fpotnote

MPM BIOVENTURES 2014 LLC - > 10% Owner see fpotnote

MPM BIOVENTURES 2014 GP LLC - > 10% Owner see fpotnote

MPM BIOVENTURES 2018 (B), L.P. - > 10% Owner see fpotnote

MPM ASSET MANAGEMENT INVESTORS BV2018 LLC - > 10% Owner see fpotnote

2021-12-02 18:53:51 -0500 2021-12-02 S 7,430 $34.83 d 2,935,301 indirect yes -7.6393 1.7806 1.7806 6 -7.6393 2

DETHEUX MICHEL - Officer CHIEF EXECUTIVE OFFICER

2021-12-22 20:01:53 -0500 2021-12-02 G 106,200 d 37,800 direct

MPM BIOVENTURES 2018, L.P. - > 10% Owner see footnote

MPM BIOVENTURES 2018 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2018 GP LLC - > 10% Owner see footnote

2021-12-02 18:56:17 -0500 2021-12-02 S 29,757 $33.74 d 2,942,731 indirect yes -7.6393 1.7806 1.7806 6 -7.6393 2

MPM BIOVENTURES 2014, L.P. - > 10% Owner see footnote

EVNIN LUKE - > 10% Owner see footnote

FOLEY TODD - > 10% Owner see footnote

MPM BIOVENTURES 2014 (B), L.P. - > 10% Owner see footnote

MPM ASSET MANAGEMENT INVESTORS BV2014 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2014 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2014 GP LLC - > 10% Owner see footnote

MPM BIOVENTURES 2018 (B), L.P. - > 10% Owner see footnote

MPM ASSET MANAGEMENT INVESTORS BV2018 LLC - > 10% Owner see footnote

2021-12-02 18:53:51 -0500 2021-12-01 S 6,042 $33.82 d 2,978,841 indirect yes -7.6393 1.7806 1.7806 6 -7.6393 2

GADICKE ANSBERT - > 10% Owner see footnote

UBS ONCOLOGY IMPACT FUND L.P. - > 10% Owner see footnote

BIOIMPACT CAPITAL LLC - > 10% Owner see footnote

ONCOLOGY IMPACT FUND (CAYMAN) MANAGEMENT L.P. - > 10% Owner see footnote

2021-12-02 18:53:00 -0500 2021-12-01 S 10,111 $33.82 d 4,886,448 indirect yes -7.6393 1.7806 1.7806 6 -7.6393 2

MPM BIOVENTURES 2018, L.P. - > 10% Owner see footnote

MPM BIOVENTURES 2018 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2018 GP LLC - > 10% Owner see footnote

2021-12-02 18:56:17 -0500 2021-12-01 S 896 $35.34 d 2,972,488 indirect yes -7.6393 1.7806 1.7806 6 -7.6393 2

MPM BIOVENTURES 2014, L.P. - > 10% Owner see footnote

EVNIN LUKE - > 10% Owner see footnote

FOLEY TODD - > 10% Owner see footnote

MPM BIOVENTURES 2014 (B), L.P. - > 10% Owner see footnote

MPM ASSET MANAGEMENT INVESTORS BV2014 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2014 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2014 GP LLC - > 10% Owner see footnote

MPM BIOVENTURES 2018 (B), L.P. - > 10% Owner see footnote

MPM ASSET MANAGEMENT INVESTORS BV2018 LLC - > 10% Owner see footnote

2021-12-02 18:53:51 -0500 2021-12-01 S 896 $35.34 d 2,972,488 indirect yes -7.6393 1.7806 1.7806 6 -7.6393 2

MPM BIOVENTURES 2018, L.P. - > 10% Owner see footnote

MPM BIOVENTURES 2018 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2018 GP LLC - > 10% Owner see footnote

2021-12-02 18:56:17 -0500 2021-12-01 S 5,457 $34.61 d 2,973,384 indirect yes -7.6393 1.7806 1.7806 6 -7.6393 2

GADICKE ANSBERT - > 10% Owner see footnote

UBS ONCOLOGY IMPACT FUND L.P. - > 10% Owner see footnote

BIOIMPACT CAPITAL LLC - > 10% Owner see footnote

ONCOLOGY IMPACT FUND (CAYMAN) MANAGEMENT L.P. - > 10% Owner see footnote

2021-12-02 18:53:00 -0500 2021-12-01 S 1,500 $35.34 d 4,875,817 indirect yes -7.6393 1.7806 1.7806 6 -7.6393 2

MPM BIOVENTURES 2014, L.P. - > 10% Owner see footnote

EVNIN LUKE - > 10% Owner see footnote

FOLEY TODD - > 10% Owner see footnote

MPM BIOVENTURES 2014 (B), L.P. - > 10% Owner see footnote

MPM ASSET MANAGEMENT INVESTORS BV2014 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2014 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2014 GP LLC - > 10% Owner see footnote

MPM BIOVENTURES 2018 (B), L.P. - > 10% Owner see footnote

MPM ASSET MANAGEMENT INVESTORS BV2018 LLC - > 10% Owner see footnote

2021-12-02 18:53:51 -0500 2021-12-01 S 5,457 $34.61 d 2,973,384 indirect yes -7.6393 1.7806 1.7806 6 -7.6393 2

MPM BIOVENTURES 2018, L.P. - > 10% Owner see footnote

MPM BIOVENTURES 2018 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2018 GP LLC - > 10% Owner see footnote

2021-12-02 18:56:17 -0500 2021-12-01 S 6,042 $33.82 d 2,978,841 indirect yes -7.6393 1.7806 1.7806 6 -7.6393 2

GADICKE ANSBERT - > 10% Owner see footnote

UBS ONCOLOGY IMPACT FUND L.P. - > 10% Owner see footnote

BIOIMPACT CAPITAL LLC - > 10% Owner see footnote

ONCOLOGY IMPACT FUND (CAYMAN) MANAGEMENT L.P. - > 10% Owner see footnote

2021-12-02 18:53:00 -0500 2021-12-01 S 9,131 $34.61 d 4,877,317 indirect yes -7.6393 1.7806 1.7806 6 -7.6393 2

MPM BIOVENTURES 2018, L.P. - > 10% Owner see footnote

MPM BIOVENTURES 2018 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2018 GP LLC - > 10% Owner see footnote

2021-12-02 18:56:17 -0500 2021-11-30 S 28,076 $35.19 d 2,984,883 indirect yes -7.6393 1.7806 1.7806 6 -7.6393 2

MPM BIOVENTURES 2014, L.P. - > 10% Owner see footnote

EVNIN LUKE - > 10% Owner see footnote

FOLEY TODD - > 10% Owner see footnote

MPM BIOVENTURES 2014 (B), L.P. - > 10% Owner see footnote

MPM ASSET MANAGEMENT INVESTORS BV2014 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2014 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2014 GP LLC - > 10% Owner see footnote

MPM BIOVENTURES 2018 (B), L.P. - > 10% Owner see footnote

MPM ASSET MANAGEMENT INVESTORS BV2018 LLC - > 10% Owner see footnote

2021-12-02 18:53:51 -0500 2021-11-30 S 28,076 $35.19 d 2,984,883 indirect yes -7.6393 1.7806 1.7806 6 -7.6393 2

MPM BIOVENTURES 2018, L.P. - > 10% Owner see footnote

MPM BIOVENTURES 2018 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2018 GP LLC - > 10% Owner see footnote

2021-12-02 18:56:17 -0500 2021-11-30 S 5,861 $34.62 d 3,012,959 indirect yes -7.6393 1.7806 1.7806 6 -7.6393 2

GADICKE ANSBERT - > 10% Owner see footnote

UBS ONCOLOGY IMPACT FUND L.P. - > 10% Owner see footnote

BIOIMPACT CAPITAL LLC - > 10% Owner see footnote

ONCOLOGY IMPACT FUND (CAYMAN) MANAGEMENT L.P. - > 10% Owner see footnote

2021-12-02 18:53:00 -0500 2021-11-30 S 46,992 $35.19 d 4,896,559 indirect yes -7.6393 1.7806 1.7806 6 -7.6393 2

MPM BIOVENTURES 2014, L.P. - > 10% Owner see footnote

EVNIN LUKE - > 10% Owner see footnote

FOLEY TODD - > 10% Owner see footnote

MPM BIOVENTURES 2014 (B), L.P. - > 10% Owner see footnote

MPM ASSET MANAGEMENT INVESTORS BV2014 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2014 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2014 GP LLC - > 10% Owner see footnote

MPM BIOVENTURES 2018 (B), L.P. - > 10% Owner see footnote

MPM ASSET MANAGEMENT INVESTORS BV2018 LLC - > 10% Owner see footnote

2021-12-02 18:53:51 -0500 2021-11-30 S 5,861 $34.62 d 3,012,959 indirect yes -7.6393 1.7806 1.7806 6 -7.6393 2

GADICKE ANSBERT - > 10% Owner see footnote

UBS ONCOLOGY IMPACT FUND L.P. - > 10% Owner see footnote

BIOIMPACT CAPITAL LLC - > 10% Owner see footnote

ONCOLOGY IMPACT FUND (CAYMAN) MANAGEMENT L.P. - > 10% Owner see footnote

2021-12-02 18:53:00 -0500 2021-11-30 S 9,809 $34.62 d 4,943,551 indirect yes -7.6393 1.7806 1.7806 6 -7.6393 2

GADICKE ANSBERT - > 10% Owner see footnote

UBS ONCOLOGY IMPACT FUND L.P. - > 10% Owner see footnote

BIOIMPACT CAPITAL LLC - > 10% Owner see footnote

ONCOLOGY IMPACT FUND (CAYMAN) MANAGEMENT L.P. - > 10% Owner see footnote

2021-11-30 16:49:31 -0500 2021-11-29 S 16,856 $34.46 d 4,953,860 indirect yes 5.442 4.4498 17.4083 43.8966 19 -3.3073 4

MPM BIOVENTURES 2018, L.P. - > 10% Owner see footnote

MPM BIOVENTURES 2018 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2018 GP LLC - > 10% Owner see footnote

2021-11-30 16:57:53 -0500 2021-11-29 S 298 $35.37 d 3,018,820 indirect yes 5.442 4.4498 17.4083 43.8966 19 -3.3073 4

MPM BIOVENTURES 2014, L.P. - > 10% Owner see footnote

EVNIN LUKE - > 10% Owner see footnote

FOLEY TODD - > 10% Owner see footnote

MPM BIOVENTURES 2014 (B), L.P. - > 10% Owner see footnote

MPM ASSET MANAGEMENT INVESTORS BV2014 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2014 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2014 GP LLC - > 10% Owner see footnote

MPM BIOVENTURES 2018 (B), L.P. - > 10% Owner see footnote

MPM ASSET MANAGEMENT INVESTORS BV2018 LLC - > 10% Owner see footnote

2021-11-30 16:53:46 -0500 2021-11-29 S 298 $35.37 d 3,018,820 indirect yes 5.442 4.4498 17.4083 43.8966 19 -3.3073 4

MPM BIOVENTURES 2018, L.P. - > 10% Owner see footnote

MPM BIOVENTURES 2018 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2018 GP LLC - > 10% Owner see footnote

2021-11-30 16:57:53 -0500 2021-11-29 S 10,073 $34.46 d 3,019,118 indirect yes 5.442 4.4498 17.4083 43.8966 19 -3.3073 4

GADICKE ANSBERT - > 10% Owner see footnote

UBS ONCOLOGY IMPACT FUND L.P. - > 10% Owner see footnote

BIOIMPACT CAPITAL LLC - > 10% Owner see footnote

ONCOLOGY IMPACT FUND (CAYMAN) MANAGEMENT L.P. - > 10% Owner see footnote

2021-11-30 16:49:31 -0500 2021-11-29 S 500 $35.37 d 4,953,360 indirect yes 5.442 4.4498 17.4083 43.8966 19 -3.3073 4

MPM BIOVENTURES 2014, L.P. - > 10% Owner see footnote

EVNIN LUKE - > 10% Owner see footnote

FOLEY TODD - > 10% Owner see footnote

MPM BIOVENTURES 2014 (B), L.P. - > 10% Owner see footnote

MPM ASSET MANAGEMENT INVESTORS BV2014 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2014 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2014 GP LLC - > 10% Owner see footnote

MPM BIOVENTURES 2018 (B), L.P. - > 10% Owner see footnote

MPM ASSET MANAGEMENT INVESTORS BV2018 LLC - > 10% Owner see footnote

2021-11-30 16:53:46 -0500 2021-11-29 S 10,073 $34.46 d 3,019,118 indirect yes 5.442 4.4498 17.4083 43.8966 19 -3.3073 4

MPM BIOVENTURES 2014, L.P. - > 10% Owner see footnote

EVNIN LUKE - > 10% Owner see footnote

FOLEY TODD - > 10% Owner see footnote

MPM BIOVENTURES 2014 (B), L.P. - > 10% Owner see footnote

MPM ASSET MANAGEMENT INVESTORS BV2014 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2014 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2014 GP LLC - > 10% Owner see footnote

MPM BIOVENTURES 2018 (B), L.P. - > 10% Owner see footnote

MPM ASSET MANAGEMENT INVESTORS BV2018 LLC - > 10% Owner see footnote

2021-11-30 16:53:46 -0500 2021-11-26 S 6,129 $36.03 d 3,029,191 indirect yes 5.442 4.4498 17.4083 43.8966 19 -3.3073 4

MPM BIOVENTURES 2018, L.P. - > 10% Owner see footnote

MPM BIOVENTURES 2018 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2018 GP LLC - > 10% Owner see footnote

2021-11-30 16:57:53 -0500 2021-11-26 S 6,545 $35.49 d 3,035,320 indirect yes 5.442 4.4498 17.4083 43.8966 19 -3.3073 4

GADICKE ANSBERT - > 10% Owner see footnote

UBS ONCOLOGY IMPACT FUND L.P. - > 10% Owner see footnote

BIOIMPACT CAPITAL LLC - > 10% Owner see footnote

ONCOLOGY IMPACT FUND (CAYMAN) MANAGEMENT L.P. - > 10% Owner see footnote

2021-11-30 16:49:31 -0500 2021-11-26 S 10,258 $36.03 d 4,970,716 indirect yes 5.442 4.4498 17.4083 43.8966 19 -3.3073 4

MPM BIOVENTURES 2014, L.P. - > 10% Owner see footnote

EVNIN LUKE - > 10% Owner see footnote

FOLEY TODD - > 10% Owner see footnote

MPM BIOVENTURES 2014 (B), L.P. - > 10% Owner see footnote

MPM ASSET MANAGEMENT INVESTORS BV2014 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2014 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2014 GP LLC - > 10% Owner see footnote

MPM BIOVENTURES 2018 (B), L.P. - > 10% Owner see footnote

MPM ASSET MANAGEMENT INVESTORS BV2018 LLC - > 10% Owner see footnote

2021-11-30 16:53:46 -0500 2021-11-26 S 6,545 $35.49 d 3,035,320 indirect yes 5.442 4.4498 17.4083 43.8966 19 -3.3073 4

GADICKE ANSBERT - > 10% Owner see footnote

UBS ONCOLOGY IMPACT FUND L.P. - > 10% Owner see footnote

BIOIMPACT CAPITAL LLC - > 10% Owner see footnote

ONCOLOGY IMPACT FUND (CAYMAN) MANAGEMENT L.P. - > 10% Owner see footnote

2021-11-30 16:49:31 -0500 2021-11-26 S 10,952 $35.49 d 4,980,974 indirect yes 5.442 4.4498 17.4083 43.8966 19 -3.3073 4

MPM BIOVENTURES 2018, L.P. - > 10% Owner see footnote

MPM BIOVENTURES 2018 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2018 GP LLC - > 10% Owner see footnote

2021-11-30 16:57:53 -0500 2021-11-26 S 6,129 $36.03 d 3,029,191 indirect yes 5.442 4.4498 17.4083 43.8966 19 -3.3073 4

GADICKE ANSBERT - > 10% Owner see footnote

UBS ONCOLOGY IMPACT FUND L.P. - > 10% Owner see footnote

BIOIMPACT CAPITAL LLC - > 10% Owner see footnote

ONCOLOGY IMPACT FUND (CAYMAN) MANAGEMENT L.P. - > 10% Owner see footnote

2021-11-24 18:38:10 -0500 2021-11-24 S 8,147 $35.20 d 5,044,587 indirect yes -1.9351 -0.9106 18.9528 36.1981 22 -8.4804 7

MPM BIOVENTURES 2014, L.P. - > 10% Owner see footnote

EVNIN LUKE - > 10% Owner see footnote

FOLEY TODD - > 10% Owner see footnote

MPM BIOVENTURES 2014 (B), L.P. - > 10% Owner see footnote

MPM ASSET MANAGEMENT INVESTORS BV2014 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2014 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2014 GP LLC - > 10% Owner see footnote

MPM BIOVENTURES 2018 (B), L.P. - > 10% Owner see footnote

MPM ASSET MANAGEMENT INVESTORS BV2018 LLC - > 10% Owner see footnote

2021-11-24 18:34:41 -0500 2021-11-24 S 18,343 $36.05 d 3,054,991 indirect yes -1.9351 -0.9106 18.9528 36.1981 22 -8.4804 7

MPM BIOVENTURES 2018, L.P. - > 10% Owner see footnote

MPM BIOVENTURES 2018 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2018 GP LLC - > 10% Owner see footnote

2021-11-24 18:35:58 -0500 2021-11-24 S 18,343 $36.05 d 3,054,991 indirect yes -1.9351 -0.9106 18.9528 36.1981 22 -8.4804 7

GADICKE ANSBERT - > 10% Owner see footnote

UBS ONCOLOGY IMPACT FUND L.P. - > 10% Owner see footnote

BIOIMPACT CAPITAL LLC - > 10% Owner see footnote

ONCOLOGY IMPACT FUND (CAYMAN) MANAGEMENT L.P. - > 10% Owner see footnote

2021-11-24 18:38:10 -0500 2021-11-24 S 21,965 $37.02 d 4,991,926 indirect yes -1.9351 -0.9106 18.9528 36.1981 22 -8.4804 7

MPM BIOVENTURES 2014, L.P. - > 10% Owner see footnote

EVNIN LUKE - > 10% Owner see footnote

FOLEY TODD - > 10% Owner see footnote

MPM BIOVENTURES 2014 (B), L.P. - > 10% Owner see footnote

MPM ASSET MANAGEMENT INVESTORS BV2014 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2014 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2014 GP LLC - > 10% Owner see footnote

MPM BIOVENTURES 2018 (B), L.P. - > 10% Owner see footnote

MPM ASSET MANAGEMENT INVESTORS BV2018 LLC - > 10% Owner see footnote

2021-11-24 18:34:41 -0500 2021-11-24 S 4,868 $35.20 d 3,073,334 indirect yes -1.9351 -0.9106 18.9528 36.1981 22 -8.4804 7

MPM BIOVENTURES 2018, L.P. - > 10% Owner see footnote

MPM BIOVENTURES 2018 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2018 GP LLC - > 10% Owner see footnote

2021-11-24 18:35:58 -0500 2021-11-24 S 4,868 $35.20 d 3,073,334 indirect yes -1.9351 -0.9106 18.9528 36.1981 22 -8.4804 7

GADICKE ANSBERT - > 10% Owner see footnote

UBS ONCOLOGY IMPACT FUND L.P. - > 10% Owner see footnote

BIOIMPACT CAPITAL LLC - > 10% Owner see footnote

ONCOLOGY IMPACT FUND (CAYMAN) MANAGEMENT L.P. - > 10% Owner see footnote

2021-11-24 18:38:10 -0500 2021-11-24 S 30,696 $36.05 d 5,013,891 indirect yes -1.9351 -0.9106 18.9528 36.1981 22 -8.4804 7

MPM BIOVENTURES 2014, L.P. - > 10% Owner see footnote

EVNIN LUKE - > 10% Owner see footnote

FOLEY TODD - > 10% Owner see footnote

MPM BIOVENTURES 2014 (B), L.P. - > 10% Owner see footnote

MPM ASSET MANAGEMENT INVESTORS BV2014 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2014 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2014 GP LLC - > 10% Owner see footnote

MPM BIOVENTURES 2018 (B), L.P. - > 10% Owner see footnote

MPM ASSET MANAGEMENT INVESTORS BV2018 LLC - > 10% Owner see footnote

2021-11-24 18:34:41 -0500 2021-11-24 S 13,126 $37.02 d 3,041,865 indirect yes -1.9351 -0.9106 18.9528 36.1981 22 -8.4804 7

MPM BIOVENTURES 2018, L.P. - > 10% Owner see footnote

MPM BIOVENTURES 2018 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2018 GP LLC - > 10% Owner see footnote

2021-11-24 18:35:58 -0500 2021-11-24 S 13,126 $37.02 d 3,041,865 indirect yes -1.9351 -0.9106 18.9528 36.1981 22 -8.4804 7

MPM BIOVENTURES 2014, L.P. - > 10% Owner see footnote

EVNIN LUKE - > 10% Owner see footnote

FOLEY TODD - > 10% Owner see footnote

MPM BIOVENTURES 2014 (B), L.P. - > 10% Owner see footnote

MPM ASSET MANAGEMENT INVESTORS BV2014 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2014 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2014 GP LLC - > 10% Owner see footnote

MPM BIOVENTURES 2018 (B), L.P. - > 10% Owner see footnote

MPM ASSET MANAGEMENT INVESTORS BV2018 LLC - > 10% Owner see footnote

2021-11-24 18:34:41 -0500 2021-11-23 S 19,645 $36.21 d 3,078,561 indirect yes -1.9351 -0.9106 18.9528 36.1981 22 -8.4804 7

MPM BIOVENTURES 2018, L.P. - > 10% Owner see footnote

MPM BIOVENTURES 2018 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2018 GP LLC - > 10% Owner see footnote

2021-11-24 18:35:58 -0500 2021-11-23 S 19,645 $36.21 d 3,078,561 indirect yes -1.9351 -0.9106 18.9528 36.1981 22 -8.4804 7

DETHEUX MICHEL - Officer CHIEF EXECUTIVE OFFICER

2021-11-24 19:59:14 -0500 2021-11-23 S 14,500 $36.08 d 78,200 direct yes -1.9351 -0.9106 18.9528 36.1981 22 -8.4804 7

GADICKE ANSBERT - > 10% Owner see footnote

UBS ONCOLOGY IMPACT FUND L.P. - > 10% Owner see footnote

BIOIMPACT CAPITAL LLC - > 10% Owner see footnote

ONCOLOGY IMPACT FUND (CAYMAN) MANAGEMENT L.P. - > 10% Owner see footnote

2021-11-24 18:38:10 -0500 2021-11-23 S 600 $36.50 d 5,052,734 indirect yes -1.9351 -0.9106 18.9528 36.1981 22 -8.4804 7

GADICKE ANSBERT - > 10% Owner see footnote

UBS ONCOLOGY IMPACT FUND L.P. - > 10% Owner see footnote

BIOIMPACT CAPITAL LLC - > 10% Owner see footnote

ONCOLOGY IMPACT FUND (CAYMAN) MANAGEMENT L.P. - > 10% Owner see footnote

2021-11-24 18:38:10 -0500 2021-11-23 S 32,876 $36.21 d 5,053,334 indirect yes -1.9351 -0.9106 18.9528 36.1981 22 -8.4804 7

MPM BIOVENTURES 2014, L.P. - > 10% Owner see footnote

EVNIN LUKE - > 10% Owner see footnote

FOLEY TODD - > 10% Owner see footnote

MPM BIOVENTURES 2014 (B), L.P. - > 10% Owner see footnote

MPM ASSET MANAGEMENT INVESTORS BV2014 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2014 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2014 GP LLC - > 10% Owner see footnote

MPM BIOVENTURES 2018 (B), L.P. - > 10% Owner see footnote

MPM ASSET MANAGEMENT INVESTORS BV2018 LLC - > 10% Owner see footnote

2021-11-24 18:34:41 -0500 2021-11-23 S 359 $36.50 d 3,078,202 indirect yes -1.9351 -0.9106 18.9528 36.1981 22 -8.4804 7

MPM BIOVENTURES 2018, L.P. - > 10% Owner see footnote

MPM BIOVENTURES 2018 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2018 GP LLC - > 10% Owner see footnote

2021-11-24 18:35:58 -0500 2021-11-23 S 359 $36.50 d 3,078,202 indirect yes -1.9351 -0.9106 18.9528 36.1981 22 -8.4804 7

GADICKE ANSBERT - > 10% Owner see footnote

UBS ONCOLOGY IMPACT FUND L.P. - > 10% Owner see footnote

BIOIMPACT CAPITAL LLC - > 10% Owner see footnote

ONCOLOGY IMPACT FUND (CAYMAN) MANAGEMENT L.P. - > 10% Owner see footnote

2021-11-24 18:38:10 -0500 2021-11-22 S 15,575 $37.16 d 5,105,986 indirect yes -1.9351 -0.9106 18.9528 36.1981 22 -8.4804 7

MPM BIOVENTURES 2014, L.P. - > 10% Owner see footnote

EVNIN LUKE - > 10% Owner see footnote

FOLEY TODD - > 10% Owner see footnote

MPM BIOVENTURES 2014 (B), L.P. - > 10% Owner see footnote

MPM ASSET MANAGEMENT INVESTORS BV2014 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2014 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2014 GP LLC - > 10% Owner see footnote

MPM BIOVENTURES 2018 (B), L.P. - > 10% Owner see footnote

MPM ASSET MANAGEMENT INVESTORS BV2018 LLC - > 10% Owner see footnote

2021-11-24 18:34:41 -0500 2021-11-22 S 11,807 $37.81 d 3,098,206 indirect yes -1.9351 -0.9106 18.9528 36.1981 22 -8.4804 7

MPM BIOVENTURES 2018, L.P. - > 10% Owner see footnote

MPM BIOVENTURES 2018 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2018 GP LLC - > 10% Owner see footnote

2021-11-24 18:35:58 -0500 2021-11-22 S 11,807 $37.81 d 3,098,206 indirect yes -1.9351 -0.9106 18.9528 36.1981 22 -8.4804 7

DETHEUX MICHEL - Officer CHIEF EXECUTIVE OFFICER

2021-11-24 19:59:14 -0500 2021-11-22 M 16,263 $12.45 a 92,700 direct -1.9351 -0.9106 18.9528 36.1981 22 -8.4804 7

MPM BIOVENTURES 2018, L.P. - > 10% Owner see footnote

MPM BIOVENTURES 2018 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2018 GP LLC - > 10% Owner see footnote

2021-11-24 18:35:58 -0500 2021-11-22 S 9,307 $37.16 d 3,110,013 indirect yes -1.9351 -0.9106 18.9528 36.1981 22 -8.4804 7

MPM BIOVENTURES 2014, L.P. - > 10% Owner see footnote

EVNIN LUKE - > 10% Owner see footnote

FOLEY TODD - > 10% Owner see footnote

MPM BIOVENTURES 2014 (B), L.P. - > 10% Owner see footnote

MPM ASSET MANAGEMENT INVESTORS BV2014 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2014 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2014 GP LLC - > 10% Owner see footnote

MPM BIOVENTURES 2018 (B), L.P. - > 10% Owner see footnote

MPM ASSET MANAGEMENT INVESTORS BV2018 LLC - > 10% Owner see footnote

2021-11-24 18:34:41 -0500 2021-11-22 S 9,307 $37.16 d 3,110,013 indirect yes -1.9351 -0.9106 18.9528 36.1981 22 -8.4804 7

GADICKE ANSBERT - > 10% Owner see footnote

UBS ONCOLOGY IMPACT FUND L.P. - > 10% Owner see footnote

BIOIMPACT CAPITAL LLC - > 10% Owner see footnote

ONCOLOGY IMPACT FUND (CAYMAN) MANAGEMENT L.P. - > 10% Owner see footnote

2021-11-24 18:38:10 -0500 2021-11-22 S 19,758 $37.81 d 5,086,210 indirect yes -1.9351 -0.9106 18.9528 36.1981 22 -8.4804 7

DETHEUX MICHEL - Officer CHIEF EXECUTIVE OFFICER

2021-11-24 19:59:14 -0500 2021-11-22 M 16,263 d 0 direct

LAGER JOANNE JENKINS - Officer CHIEF MEDICAL OFFICER

2021-11-19 20:00:20 -0500 2021-11-18 M 28,000 $4.30 a 28,000 direct yes -0.9519 -3.9978 14.1148 30.1605 25 -12.5374 10

LAGER JOANNE JENKINS - Officer CHIEF MEDICAL OFFICER

2021-11-19 20:00:20 -0500 2021-11-18 M 28,000 d 206,938 direct yes

LAGER JOANNE JENKINS - Officer CHIEF MEDICAL OFFICER

2021-11-19 20:00:20 -0500 2021-11-18 S 28,000 $34.50 d 0 direct yes -0.9519 -3.9978 14.1148 30.1605 25 -12.5374 10

MPM BIOVENTURES 2018, L.P. - > 10% Owner see footnote

MPM BIOVENTURES 2018 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2018 GP LLC - > 10% Owner see footnote

2021-11-24 18:35:58 -0500 2021-11-17 J 15,671 d 3,119,320 indirect -1.9351 -0.9106 18.9528 36.1981 22 -8.4804 7

MPM BIOVENTURES 2014, L.P. - > 10% Owner see footnote

EVNIN LUKE - > 10% Owner see footnote

FOLEY TODD - > 10% Owner see footnote

MPM BIOVENTURES 2014 (B), L.P. - > 10% Owner see footnote

MPM ASSET MANAGEMENT INVESTORS BV2014 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2014 LLC - > 10% Owner see footnote

MPM BIOVENTURES 2014 GP LLC - > 10% Owner see footnote

MPM BIOVENTURES 2018 (B), L.P. - > 10% Owner see footnote

MPM ASSET MANAGEMENT INVESTORS BV2018 LLC - > 10% Owner see footnote

2021-11-24 18:34:41 -0500 2021-11-17 J 15,671 d 3,119,320 indirect -1.9351 -0.9106 18.9528 36.1981 22 -8.4804 7

GADICKE ANSBERT - > 10% Owner see footnote

UBS ONCOLOGY IMPACT FUND L.P. - > 10% Owner see footnote

BIOIMPACT CAPITAL LLC - > 10% Owner see footnote

ONCOLOGY IMPACT FUND (CAYMAN) MANAGEMENT L.P. - > 10% Owner see footnote

2021-11-24 18:38:10 -0500 2021-11-17 J 15,671 d 5,121,543 indirect -1.9351 -0.9106 18.9528 36.1981 22 -8.4804 7

* -

Transaction Code Definitions
Code Definition
A Grant, award or other acquisition pursuant to Rule 16b-3(d)
C Conversion of derivative security
D Disposition to the issuer of issuer equity securities pursuant to Rule 16b-3(e)
E Expiration of short derivative position
F Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3
G Bona fide gift
H Expiration (or cancellation) of long derivative position with value received
I Discretionary transaction in accordance with Rule 16b-3(f) resulting in acquisition or disposition of issuer securities
J Other acquisition or disposition
L Small acquisition under Rule 16a-6
M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3
O Exercise of out-of-the-money derivative security
P Open market or private purchase of non-derivative or derivative security
S Open market or private sale of non-derivative or derivative security
U Disposition pursuant to a tender of shares in a change of control transaction
W Acquisition or disposition by will or the laws of descent and distribution
X Exercise of in-the-money or at-the-money derivative security
Z Deposit into or withdrawal from voting trust

IBR Securities Loan Availability

Updated throughout the day, this shows the number of shares available to borrow. Data provided by Interactive Brokers

Security Date/Time Rebate Rate Fee Rate Shares Available
ITEOS THERAPEUTICS INC ITOS 2022-01-14 22:15:03 UTC -0.4365 0.5065 950000
ITEOS THERAPEUTICS INC ITOS 2022-01-14 21:45:03 UTC -0.4365 0.5065 950000
ITEOS THERAPEUTICS INC ITOS 2022-01-14 21:15:03 UTC -0.4365 0.5065 950000
ITEOS THERAPEUTICS INC ITOS 2022-01-14 20:45:03 UTC -0.4365 0.5065 950000
ITEOS THERAPEUTICS INC ITOS 2022-01-14 20:15:03 UTC -0.4365 0.5065 950000
ITEOS THERAPEUTICS INC ITOS 2022-01-14 19:45:03 UTC -0.4365 0.5065 950000
ITEOS THERAPEUTICS INC ITOS 2022-01-14 19:15:04 UTC -0.4365 0.5065 950000
ITEOS THERAPEUTICS INC ITOS 2022-01-14 18:45:04 UTC -0.4365 0.5065 950000
ITEOS THERAPEUTICS INC ITOS 2022-01-14 18:15:03 UTC -0.4365 0.5065 950000
ITEOS THERAPEUTICS INC ITOS 2022-01-14 17:45:03 UTC -0.4365 0.5065 950000
ITEOS THERAPEUTICS INC ITOS 2022-01-14 17:15:03 UTC -0.4365 0.5065 950000
ITEOS THERAPEUTICS INC ITOS 2022-01-14 16:45:04 UTC -0.4262 0.4962 950000
ITEOS THERAPEUTICS INC ITOS 2022-01-14 16:15:03 UTC -0.4262 0.4962 950000
ITEOS THERAPEUTICS INC ITOS 2022-01-14 15:45:03 UTC -0.4262 0.4962 950000
ITEOS THERAPEUTICS INC ITOS 2022-01-14 15:15:03 UTC -0.4262 0.4962 950000
ITEOS THERAPEUTICS INC ITOS 2022-01-14 14:45:03 UTC -0.4262 0.4962 950000
ITEOS THERAPEUTICS INC ITOS 2022-01-14 14:15:03 UTC -0.4262 0.4962 950000
ITEOS THERAPEUTICS INC ITOS 2022-01-14 13:45:02 UTC -0.4262 0.4962 950000
ITEOS THERAPEUTICS INC ITOS 2022-01-14 13:15:03 UTC -0.4262 0.4962 950000
ITEOS THERAPEUTICS INC ITOS 2022-01-14 12:45:03 UTC -0.4262 0.4962 950000

Current Active Short Positions

Holder Issuer Net Short Position Position Date Origin

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