Prelude Therapeutics Inc. (PRLD)

HEALTH CARE: PHARMACEUTICALS
SIC: PHARMACEUTICAL PREPARATIONS

200 POWDER MILL ROAD WILMINGTON, DE 19803

Prelude Therapeutics is a clinical-stage precision oncology company developing innovative drug candidates targeting critical cancer cell pathways. The Company’s lead product candidates are designed to be oral, potent, and selective inhibitors of PRMT5. Prelude’s first clinical candidate, PRT543, is in Phase 1 development for advanced solid tumors and select myeloid malignancies. Prelude is also advancing PRT811, a second PRMT5 inhibitor optimized for high brain exposure, in a Phase 1 clinical trial including glioblastoma multiforme (GBM). The Company’s pipeline also includes its third clinical candidate, PRT1419, an orally available MCL1 inhibitor in Phase 1 development for patients with relapsed/refractory hematologic malignancies, and its two most advanced preclinical candidates, PRT2527, a CDK9 inhibitor, and PRT-SCA2, a SMARCA2 protein degrader.

Data as of 2021-06-13 10:20:06 -0400
Market Cap1.465 Billion Shares Outstanding46.958 Million Avg 30-day Volume201.892 Thousand
P/E Ratio0.0 Dividend Yield0.0 EPS0
Price/Sales Debt to Equity EBITDA
Price to Book Value0.0 Forward PE-14.33 Enterprise Value
Total Cash Current Debt Gross Profit
BETA0.0 52-week High/Low95.38 / 23.69 Next Earnings Date2021-08-05 Price to Cash FLow (P/CF) -9999999.0
Data provided by IEX Cloud
View SEC Filings from PRLD instead.
Q1 2021 All 13F Filers Prior Change Hedge Funds 1 Prior Change
In top 10: 2 2 0.0% 2 (0.12%) 2 (0.12%) 0.0%
Funds Holding: 59 52 13.46% 16 (0.94%) 16 (0.93%) 0.0%
13F shares: 32.515 Million 34.651 Million -6.16% 21.827 Million 27.569 Million -20.83%
% Ownership 69.7967 79.2879 -11.97% 46.8532 63.0822 -25.73%
New Positions: 16 31 -48.39% 5 7 -28.57%
Increased Positions 29 7 314.29% 5 2 150.0%
Closed Positions 9 18 -50.0% 5 13 -61.54%
Reduced Positions 9 7 28.57% 5 3 66.67%
Total Calls
Total Puts
PUT/CALL Ratio
1 hedge funds and active managers as identified by whalewisdom.com through public filings.

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Funds Holding PRLD (via 13F filings)

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*Please note that if a filer hasn't submitted a 13F filing for a quarter then the filer's shares will be listed as "Sold All"

Mutual Funds Holding PRLD BETA

Active Schedule 13D and 13G filings

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Open Market Buys/Sells Last 60 Days

Open Market Buys (P)

none

Open Market Sells (S)

104.9 Thousand total shares from 20 transactions

Exercise Derivative Conversion (M)

104.9 Thousand total shares from 8 transactions

Current/Former Insiders

Insider Name Type Last Reported Shares Held Last Reported Date Filings in past year

MAURO DAVID J CHIEF MEDICAL OFFICER

  • Officer
197,610 2021-06-07 6

PIPER BRIAN CHIEF FINANCIAL OFFICER

  • Officer
272,662 2021-05-25 1

SCHERLE PEGGY CHIEF SCIENTIFIC OFFICER

  • Officer
229,380 2021-05-07 3

MOROSINI DEBORAH EVP, CHIEF OF CLINICAL AFFAIRS

  • Officer
4,767 2021-04-29 4

PIERCE CHRISTOPHER EVP AND CHIEF OF BUSINESS OPER

  • Officer
8,073 2021-04-29 4

BAKER BROS. ADVISORS LP

667, L.P.

BAKER BROS. ADVISORS (GP) LLC

BAKER BROTHERS LIFE SCIENCES LP

BAKER FELIX

BAKER JULIAN

  • Director
  • 10% Owner
10,129,012 2021-01-27 1

ORBIMED ADVISORS LLC

ORBIMED CAPITAL GP VI LLC

ORBIMED CAPITAL LLC

  • Director
  • 10% Owner
0 2021-01-11 2

BONITA DAVID P

  • Director
  • 10% Owner
0 2021-01-11 1

DIER MARDI

  • Director
10,000 2020-09-29 2

VADDI KRISHNA PRESIDENT, CEO

  • Officer
  • Director
2,674,201 2020-09-29 1

COMBS ANDREW EVP, HEAD OF CHEMISTRY

  • Officer
260,380 2020-09-29 1

SANDOR VICTOR

  • Director
0 2020-09-24 1

ORBIMED ADVISORS LLC

ORBIMED CAPITAL GP VI LLC

  • Director
  • 10% Owner
0 2020-03-27 2

FRIEDMAN PAUL A

  • Director
500,098 2020-03-27 0

Insider Transactions Last 60 Days

Reporting Owners Filing Date Trans Date Trans Code Shares Share Price Acquired
Disposed
Shares Owned after D/I 10b5 Perf 1d* Perf 5d* Perf 1m* Max Gain Max Gain Days Max Loss Max Loss Days

MAURO DAVID J - Officer CHIEF MEDICAL OFFICER

2021-06-09 18:24:28 -0400 2021-06-07 S 1,400 $30.35 d 13,600 direct yes -2.6217 0.9988 5.4307 3 -2.6217 2

MAURO DAVID J - Officer CHIEF MEDICAL OFFICER

2021-06-09 18:24:28 -0400 2021-06-07 S 12,700 $32.73 d 0 direct yes -2.6217 0.9988 5.4307 3 -2.6217 2

MAURO DAVID J - Officer CHIEF MEDICAL OFFICER

2021-06-09 18:24:28 -0400 2021-06-07 M 15,000 $1.89 a 15,000 direct -2.6217 0.9988 5.4307 3 -2.6217 2

MAURO DAVID J - Officer CHIEF MEDICAL OFFICER

2021-06-09 18:24:28 -0400 2021-06-07 S 900 $31.62 d 12,700 direct yes -2.6217 0.9988 5.4307 3 -2.6217 2

MAURO DAVID J - Officer CHIEF MEDICAL OFFICER

2021-06-09 18:24:28 -0400 2021-06-07 M 15,000 d 197,610 direct

PIPER BRIAN - Officer CHIEF FINANCIAL OFFICER

2021-05-27 17:03:20 -0400 2021-05-25 S 399 $36.09 d 0 direct yes -5.0921 -6.7894 0.0 1 -13.809 5

PIPER BRIAN - Officer CHIEF FINANCIAL OFFICER

2021-05-27 17:03:20 -0400 2021-05-25 S 3,110 $33.53 d 5,223 direct yes -5.0921 -6.7894 0.0 1 -13.809 5

PIPER BRIAN - Officer CHIEF FINANCIAL OFFICER

2021-05-27 17:03:20 -0400 2021-05-25 S 1,736 $35.45 d 399 direct yes -5.0921 -6.7894 0.0 1 -13.809 5

PIPER BRIAN - Officer CHIEF FINANCIAL OFFICER

2021-05-27 17:03:20 -0400 2021-05-25 M 8,333 $1.89 a 8,333 direct -5.0921 -6.7894 0.0 1 -13.809 5

PIPER BRIAN - Officer CHIEF FINANCIAL OFFICER

2021-05-27 17:03:20 -0400 2021-05-25 M 8,333 d 272,662 direct

PIPER BRIAN - Officer CHIEF FINANCIAL OFFICER

2021-05-27 17:03:20 -0400 2021-05-25 S 3,088 $34.11 d 2,135 direct yes -5.0921 -6.7894 0.0 1 -13.809 5

SCHERLE PEGGY - Officer CHIEF SCIENTIFIC OFFICER

2021-05-11 18:46:13 -0400 2021-05-07 S 200 $41.85 d 172,920 direct yes -11.6253 -18.5327 0.0 1 -18.5327 6

SCHERLE PEGGY - Officer CHIEF SCIENTIFIC OFFICER

2021-05-11 18:46:13 -0400 2021-05-07 M 10,000 $1.43 a 182,920 direct -11.6253 -18.5327 0.0 1 -18.5327 6

SCHERLE PEGGY - Officer CHIEF SCIENTIFIC OFFICER

2021-05-11 18:46:13 -0400 2021-05-07 S 5,836 $41.14 d 173,120 direct yes -11.6253 -18.5327 0.0 1 -18.5327 6

SCHERLE PEGGY - Officer CHIEF SCIENTIFIC OFFICER

2021-05-11 18:46:13 -0400 2021-05-07 M 10,000 d 56,460 direct

SCHERLE PEGGY - Officer CHIEF SCIENTIFIC OFFICER

2021-05-11 18:46:13 -0400 2021-05-07 S 3,964 $40.30 d 178,956 direct yes -11.6253 -18.5327 0.0 1 -18.5327 6

MAURO DAVID J - Officer CHIEF MEDICAL OFFICER

2021-05-10 16:37:57 -0400 2021-05-05 S 10,476 $40.30 d 1,109 direct yes 7.5765 -4.3468 7.5765 2 -4.9296 3

MAURO DAVID J - Officer CHIEF MEDICAL OFFICER

2021-05-10 16:37:57 -0400 2021-05-05 M 15,000 d 212,610 direct

MAURO DAVID J - Officer CHIEF MEDICAL OFFICER

2021-05-10 16:37:57 -0400 2021-05-05 S 3,415 $39.36 d 11,585 direct yes 7.5765 -4.3468 7.5765 2 -4.9296 3

MAURO DAVID J - Officer CHIEF MEDICAL OFFICER

2021-05-10 16:37:57 -0400 2021-05-05 S 1,109 $41.07 d 0 direct yes 7.5765 -4.3468 7.5765 2 -4.9296 3

MAURO DAVID J - Officer CHIEF MEDICAL OFFICER

2021-05-10 16:37:57 -0400 2021-05-05 M 15,000 $1.89 a 15,000 direct 7.5765 -4.3468 7.5765 2 -4.9296 3

PIERCE CHRISTOPHER - Officer EVP AND CHIEF OF BUSINESS OPER

2021-04-30 18:24:17 -0400 2021-04-29 M 3,295 d 4,323 direct

MOROSINI DEBORAH - Officer EVP, CHIEF OF CLINICAL AFFAIRS

2021-04-30 18:22:06 -0400 2021-04-29 M 3,223 d 4,323 direct

PIERCE CHRISTOPHER - Officer EVP AND CHIEF OF BUSINESS OPER

2021-04-30 18:24:17 -0400 2021-04-29 S 3,295 $40.29 d 3,750 direct yes -1.5563 0.5435 -20.3804 9.4368 8 -25.9881 24

MOROSINI DEBORAH - Officer EVP, CHIEF OF CLINICAL AFFAIRS

2021-04-30 18:22:06 -0400 2021-04-29 S 3,223 $40.29 d 444 direct yes -1.5563 0.5435 -20.3804 9.4368 8 -25.9881 24

PIERCE CHRISTOPHER - Officer EVP AND CHIEF OF BUSINESS OPER

2021-04-30 18:24:17 -0400 2021-04-29 M 3,295 $1.89 a 7,045 direct -1.5563 0.5435 -20.3804 9.4368 8 -25.9881 24

MOROSINI DEBORAH - Officer EVP, CHIEF OF CLINICAL AFFAIRS

2021-04-30 18:22:06 -0400 2021-04-29 M 3,223 $1.89 a 3,667 direct -1.5563 0.5435 -20.3804 9.4368 8 -25.9881 24

MAURO DAVID J - Officer CHIEF MEDICAL OFFICER

2021-04-29 17:14:44 -0400 2021-04-27 M 25,000 d 227,610 direct

MAURO DAVID J - Officer CHIEF MEDICAL OFFICER

2021-04-29 17:14:44 -0400 2021-04-27 S 7,688 $34.66 d 17,312 direct yes -2.3166 0.4102 -18.4846 6.9015 9 -27.7027 25

MAURO DAVID J - Officer CHIEF MEDICAL OFFICER

2021-04-29 17:14:44 -0400 2021-04-27 S 1,711 $36.11 d 0 direct yes -2.3166 0.4102 -18.4846 6.9015 9 -27.7027 25

MAURO DAVID J - Officer CHIEF MEDICAL OFFICER

2021-04-29 17:14:44 -0400 2021-04-27 M 25,000 $1.89 a 25,000 direct -2.3166 0.4102 -18.4846 6.9015 9 -27.7027 25

MAURO DAVID J - Officer CHIEF MEDICAL OFFICER

2021-04-29 17:14:44 -0400 2021-04-27 S 15,601 $35.68 d 1,711 direct yes -2.3166 0.4102 -18.4846 6.9015 9 -27.7027 25

MAURO DAVID J - Officer CHIEF MEDICAL OFFICER

2021-04-21 19:56:10 -0400 2021-04-19 M 25,000 $1.89 a 25,000 direct -7.2654 8.4718 -19.6783 18.7668 15 -19.6783 31

MAURO DAVID J - Officer CHIEF MEDICAL OFFICER

2021-04-21 19:56:10 -0400 2021-04-19 S 4,000 $31.27 d 0 direct yes -7.2654 8.4718 -19.6783 18.7668 15 -19.6783 31

MAURO DAVID J - Officer CHIEF MEDICAL OFFICER

2021-04-21 19:56:10 -0400 2021-04-19 S 21,000 $30.82 d 4,000 direct yes -7.2654 8.4718 -19.6783 18.7668 15 -19.6783 31

MAURO DAVID J - Officer CHIEF MEDICAL OFFICER

2021-04-21 19:56:10 -0400 2021-04-19 M 25,000 d 252,610 direct

* -

Transaction Code Definitions
Code Definition
A Grant, award or other acquisition pursuant to Rule 16b-3(d)
C Conversion of derivative security
D Disposition to the issuer of issuer equity securities pursuant to Rule 16b-3(e)
E Expiration of short derivative position
F Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3
G Bona fide gift
H Expiration (or cancellation) of long derivative position with value received
I Discretionary transaction in accordance with Rule 16b-3(f) resulting in acquisition or disposition of issuer securities
J Other acquisition or disposition
L Small acquisition under Rule 16a-6
M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3
O Exercise of out-of-the-money derivative security
P Open market or private purchase of non-derivative or derivative security
S Open market or private sale of non-derivative or derivative security
U Disposition pursuant to a tender of shares in a change of control transaction
W Acquisition or disposition by will or the laws of descent and distribution
X Exercise of in-the-money or at-the-money derivative security
Z Deposit into or withdrawal from voting trust

IBR Securities Loan Availability

Updated throughout the day, this shows the number of shares available to borrow. Data provided by Interactive Brokers

Security Date/Time Rebate Rate Fee Rate Shares Available
PRELUDE THERAPEUTICS INC PRLD 2021-06-17 22:15:03 UTC -0.7455 0.7855 60000
PRELUDE THERAPEUTICS INC PRLD 2021-06-17 21:45:03 UTC -0.7455 0.7855 60000
PRELUDE THERAPEUTICS INC PRLD 2021-06-17 21:15:03 UTC -0.7455 0.7855 60000
PRELUDE THERAPEUTICS INC PRLD 2021-06-17 20:45:04 UTC -0.7455 0.7855 60000
PRELUDE THERAPEUTICS INC PRLD 2021-06-17 20:15:03 UTC -0.7455 0.7855 60000
PRELUDE THERAPEUTICS INC PRLD 2021-06-17 19:45:03 UTC -0.7455 0.7855 60000
PRELUDE THERAPEUTICS INC PRLD 2021-06-17 19:15:03 UTC -0.7455 0.7855 60000
PRELUDE THERAPEUTICS INC PRLD 2021-06-17 18:45:04 UTC -0.6573 0.6973 60000
PRELUDE THERAPEUTICS INC PRLD 2021-06-17 18:15:03 UTC -0.6573 0.6973 50000
PRELUDE THERAPEUTICS INC PRLD 2021-06-17 17:45:03 UTC -0.6573 0.6973 50000
PRELUDE THERAPEUTICS INC PRLD 2021-06-17 17:15:03 UTC -0.6573 0.6973 50000
PRELUDE THERAPEUTICS INC PRLD 2021-06-17 16:45:03 UTC -0.6573 0.6973 50000
PRELUDE THERAPEUTICS INC PRLD 2021-06-17 16:15:02 UTC -0.6573 0.6973 50000
PRELUDE THERAPEUTICS INC PRLD 2021-06-17 15:45:03 UTC -0.6573 0.6973 50000
PRELUDE THERAPEUTICS INC PRLD 2021-06-17 15:15:03 UTC -0.6573 0.6973 50000
PRELUDE THERAPEUTICS INC PRLD 2021-06-17 14:45:02 UTC -0.7718 0.8118 50000
PRELUDE THERAPEUTICS INC PRLD 2021-06-17 14:15:03 UTC -0.7718 0.8118 50000
PRELUDE THERAPEUTICS INC PRLD 2021-06-17 13:45:03 UTC -0.7718 0.8118 50000
PRELUDE THERAPEUTICS INC PRLD 2021-06-17 13:15:03 UTC -0.7718 0.8118 50000
PRELUDE THERAPEUTICS INC PRLD 2021-06-17 12:45:02 UTC -0.7718 0.8118 50000

Current Active Short Positions

Holder Issuer Net Short Position Position Date Origin
Blackstone Alternative Investment Funds- Blackstone Alternative Multi-Strategy Fund PRLD -500.0 shares, $-21665.0 2021-03-31 N-PORT

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